@article{cba0f30e918f4f1aad80fe30a235d063,
title = "Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial",
abstract = "The mechanisms by which selective serotonin re-uptake inhibitors (SSRI) act in depressed patients remain unknown. The serotonergic neurotransmitter system and the hypothalamic-pituitary-adrenal (HPA) system may interact. The aim of the AGENDA trial was to investigate whether long-term intervention with SSRI versus placebo affects the cortisol response in the dexamethasone corticotropin-releasing hormone (DEX-CRH) test in healthy first-degree relatives to patients with major depressive disorder (MDD).",
keywords = "Adolescent, Adult, Antidepressive Agents, Citalopram, Depressive Disorder, Major, Family, Female, Humans, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Young Adult",
author = "Ulla Knorr and Maj Vinberg and Allan Hansen and Marianne Klose and Ulla Feldt-Rasmussen and Linda Hilsted and Hasselstr{\o}m, {J{\o}rgen Bo} and Ulrik Gether and Per Winkel and Christian Gluud and J{\o}rn Wetterslev and Kessing, {Lars Vedel}",
year = "2011",
doi = "10.1371/journal.pone.0021224",
language = "English",
volume = "6",
pages = "e21224",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",
}