ESBL-production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria

Frederik B Hertz; Fillip Jansåker; Kenneth O Okon; Ibrahim S Abdulmumin; Joseph O Onah; Joshua Ladan; Jenny D Knudsen

doi:10.1002/mbo3.816

ESBL-production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria

Frederik B Hertz, Fillip Jansåker, Kenneth O Okon, Ibrahim S Abdulmumin, Joseph O Onah, Joshua Ladan, Jenny D Knudsen

Klinisk Mikrobiologisk Afdeling AHH

10 Citationer (Scopus)

Abstract

The worldwide increase in infections caused by extended-spectrum beta-lactamase- (ESBL) and AmpC-producing Enterobacteriaceae (ESBL-E) is a concern. Surveillance is extensive in Europe, North America, and Asia. Yet, there is no summarizing surveillance in Africa. This study aimed to perform a preliminary investigation on the prevalence of ESBL-E in the northeastern part of Nigeria. However, of the 60 samples collected, we were able to culture 15 Escherichia coli and 7 Klebsiella spp. only. In the collection of clinical hospital samples, we found eight of 15 E. coli isolates to be ESBL (53%) and two out of seven Klebsiella spp. to be ESBL/AmpC (29%). Due to the limitations of this study, our findings cannot take a broad view on the prevalence of ESBL-E, in Nigeria and other parts of Africa. Yet, to know which genes encode ESBL in Nigeria, and to know exact prevalence of every ESBL gene would be of importance.

Originalsprog	Engelsk
Artikelnummer	e00816
Tidsskrift	MicrobiologyOpen
Vol/bind	8
Udgave nummer	9
ISSN	2045-8827
DOI	https://doi.org/10.1002/mbo3.816
Status	Udgivet - sep. 2019

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title = "ESBL-production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria",

abstract = "The worldwide increase in infections caused by extended-spectrum beta-lactamase- (ESBL) and AmpC-producing Enterobacteriaceae (ESBL-E) is a concern. Surveillance is extensive in Europe, North America, and Asia. Yet, there is no summarizing surveillance in Africa. This study aimed to perform a preliminary investigation on the prevalence of ESBL-E in the northeastern part of Nigeria. However, of the 60 samples collected, we were able to culture 15 Escherichia coli and 7 Klebsiella spp. only. In the collection of clinical hospital samples, we found eight of 15 E. coli isolates to be ESBL (53%) and two out of seven Klebsiella spp. to be ESBL/AmpC (29%). Due to the limitations of this study, our findings cannot take a broad view on the prevalence of ESBL-E, in Nigeria and other parts of Africa. Yet, to know which genes encode ESBL in Nigeria, and to know exact prevalence of every ESBL gene would be of importance.",

keywords = "Enterobacteriaceae, ESBL, Escherichia coli, Klebsiella pneumoniae, Nigeria",

author = "Hertz, {Frederik B} and Fillip Jans{\aa}ker and Okon, {Kenneth O} and Abdulmumin, {Ibrahim S} and Onah, {Joseph O} and Joshua Ladan and Knudsen, {Jenny D}",

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doi = "10.1002/mbo3.816",

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T1 - ESBL-production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria

AU - Hertz, Frederik B

AU - Jansåker, Fillip

AU - Okon, Kenneth O

AU - Abdulmumin, Ibrahim S

AU - Onah, Joseph O

AU - Ladan, Joshua

AU - Knudsen, Jenny D

PY - 2019/9

Y1 - 2019/9

N2 - The worldwide increase in infections caused by extended-spectrum beta-lactamase- (ESBL) and AmpC-producing Enterobacteriaceae (ESBL-E) is a concern. Surveillance is extensive in Europe, North America, and Asia. Yet, there is no summarizing surveillance in Africa. This study aimed to perform a preliminary investigation on the prevalence of ESBL-E in the northeastern part of Nigeria. However, of the 60 samples collected, we were able to culture 15 Escherichia coli and 7 Klebsiella spp. only. In the collection of clinical hospital samples, we found eight of 15 E. coli isolates to be ESBL (53%) and two out of seven Klebsiella spp. to be ESBL/AmpC (29%). Due to the limitations of this study, our findings cannot take a broad view on the prevalence of ESBL-E, in Nigeria and other parts of Africa. Yet, to know which genes encode ESBL in Nigeria, and to know exact prevalence of every ESBL gene would be of importance.

AB - The worldwide increase in infections caused by extended-spectrum beta-lactamase- (ESBL) and AmpC-producing Enterobacteriaceae (ESBL-E) is a concern. Surveillance is extensive in Europe, North America, and Asia. Yet, there is no summarizing surveillance in Africa. This study aimed to perform a preliminary investigation on the prevalence of ESBL-E in the northeastern part of Nigeria. However, of the 60 samples collected, we were able to culture 15 Escherichia coli and 7 Klebsiella spp. only. In the collection of clinical hospital samples, we found eight of 15 E. coli isolates to be ESBL (53%) and two out of seven Klebsiella spp. to be ESBL/AmpC (29%). Due to the limitations of this study, our findings cannot take a broad view on the prevalence of ESBL-E, in Nigeria and other parts of Africa. Yet, to know which genes encode ESBL in Nigeria, and to know exact prevalence of every ESBL gene would be of importance.

KW - Enterobacteriaceae

KW - ESBL

KW - Escherichia coli

KW - Klebsiella pneumoniae

KW - Nigeria

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U2 - 10.1002/mbo3.816

DO - 10.1002/mbo3.816

M3 - Journal article

C2 - 30801967

SN - 2045-8827

VL - 8

JO - MicrobiologyOpen

JF - MicrobiologyOpen

IS - 9

M1 - e00816

ER -

ESBL-production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria

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