TY - JOUR
T1 - ERN GENTURIS guideline on counselling on reproductive options for individuals with a cancer predisposition syndrome (including genturis)
AU - Farschtschi, Said C.
AU - Kumps, Candy
AU - Milagre, Tamara Hussong
AU - Makrythanasis, Periklis
AU - Van Tongerloo, Ariane
AU - Denayer, Ellen
AU - van Kouwen, Mariëtte
AU - Carrasco López, Estela
AU - Berghoff, Anna Sophie
AU - Testa, Salvo
AU - Cesaretti, Claudia
AU - Trevisson, Eva
AU - d’ Oliveira, Renata
AU - Fianchi, Francesca
AU - Röhl, Claas
AU - Salinas-Chaparro, Diana
AU - Slegers, Ileen
AU - Geilswijk, Marianne
AU - Suerink, Manon
AU - Spinelli, Irene
AU - Janssens, Sandra
AU - Pugh, Sarah
AU - Sønderberg Roos, Laura Kirstine
N1 - Publisher Copyright:
© The Author(s) 2026.
PY - 2026/1/13
Y1 - 2026/1/13
N2 - Cancer predisposition syndromes (CPSs), including genetic tumour risk syndromes (genturis), are a heterogeneous group of genetic disorders characterised by an increased risk of developing tumours compared to the general population. CPSs raise reproductive issues for affected individuals because of the risk of passing the disease-causing genetic alterations on to offspring. The demand for reproductive counselling is often unmet due to the lack of sufficient healthcare professionals with the specialised knowledge, experience and skill. Based on a comprehensive literature review of 851 publications and expert consensus (multidisciplinary medical experts and patient representatives), the European Reference Network on genetic tumour risk syndromes (ERN GENTURIS) developed a guideline providing 16 recommendations for reproductive counselling in CPSs. The central recommendation is to offer reproductive counselling proactively to all individuals with a CPS and their relevant family members, together with psychological support and in multidisciplinary collaborations. This guideline aims to standardize the offer of reproductive counselling for individuals with a CPS across Europe, empowers healthcare professionals for their specific tasks, and helps patients dealing with their own challenges.
AB - Cancer predisposition syndromes (CPSs), including genetic tumour risk syndromes (genturis), are a heterogeneous group of genetic disorders characterised by an increased risk of developing tumours compared to the general population. CPSs raise reproductive issues for affected individuals because of the risk of passing the disease-causing genetic alterations on to offspring. The demand for reproductive counselling is often unmet due to the lack of sufficient healthcare professionals with the specialised knowledge, experience and skill. Based on a comprehensive literature review of 851 publications and expert consensus (multidisciplinary medical experts and patient representatives), the European Reference Network on genetic tumour risk syndromes (ERN GENTURIS) developed a guideline providing 16 recommendations for reproductive counselling in CPSs. The central recommendation is to offer reproductive counselling proactively to all individuals with a CPS and their relevant family members, together with psychological support and in multidisciplinary collaborations. This guideline aims to standardize the offer of reproductive counselling for individuals with a CPS across Europe, empowers healthcare professionals for their specific tasks, and helps patients dealing with their own challenges.
UR - http://www.scopus.com/inward/record.url?scp=105027287219&partnerID=8YFLogxK
U2 - 10.1038/s41431-025-02007-4
DO - 10.1038/s41431-025-02007-4
M3 - Review
C2 - 41530368
AN - SCOPUS:105027287219
SN - 1018-4813
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
ER -