Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy

Patrick Rossignol, Joël Ménard, Renaud Fay, Finn Gustafsson, Bertram Pitt, Faiez Zannad

    118 Citationer (Scopus)

    Abstract

    The purpose of this study was to determine whether a diuretic effect may be detectable in patients treated with eplerenone, a mineralocorticoid receptor antagonist, as compared with placebo during the first month of EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival study) (n = 6,080) and whether this was associated with eplerenone's beneficial effects on cardiovascular outcomes.
    OriginalsprogEngelsk
    TidsskriftAmerican College of Cardiology. Journal
    Vol/bind58
    Udgave nummer19
    Sider (fra-til)1958-66
    Antal sider9
    ISSN0735-1097
    DOI
    StatusUdgivet - 2011

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