Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*

Claus H Nielsen; Thomas H Brix; Andrzej Gardas; J Paul Banga; Laszlo Hegedüs

doi:10.1111/j.1365-2265.2008.03245.x

Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*

Claus H Nielsen, Thomas H Brix, Andrzej Gardas, J Paul Banga, Laszlo Hegedüs

23 Citationer (Scopus)

Abstract

Thyroid peroxidase antibodies (TPOAb) are markers of autoimmune thyroid disease (AITD), including Hashimoto's thyroiditis (HT), but naturally occurring TPOAb are also detectable in healthy, euthyroid individuals. In AITD, circulating TPOAb react mainly with two immunodominant regions (IDR), IDR-A and IDR-B. The present study was undertaken in order to compare the epitope recognition pattern of TPOAb in HT patients and healthy subjects.

Originalsprog	Engelsk
Tidsskrift	Clinical Endocrinology
Vol/bind	69
Udgave nummer	4
Sider (fra-til)	664-8
Antal sider	5
ISSN	0300-0664
DOI	https://doi.org/10.1111/j.1365-2265.2008.03245.x
Status	Udgivet - 1 okt. 2008

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10.1111/j.1365-2265.2008.03245.x

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abstract = "Thyroid peroxidase antibodies (TPOAb) are markers of autoimmune thyroid disease (AITD), including Hashimoto's thyroiditis (HT), but naturally occurring TPOAb are also detectable in healthy, euthyroid individuals. In AITD, circulating TPOAb react mainly with two immunodominant regions (IDR), IDR-A and IDR-B. The present study was undertaken in order to compare the epitope recognition pattern of TPOAb in HT patients and healthy subjects.",

author = "Nielsen, {Claus H} and Brix, {Thomas H} and Andrzej Gardas and Banga, {J Paul} and Laszlo Heged{\"u}s",

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AU - Nielsen, Claus H

AU - Brix, Thomas H

AU - Gardas, Andrzej

AU - Banga, J Paul

AU - Hegedüs, Laszlo

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Thyroid peroxidase antibodies (TPOAb) are markers of autoimmune thyroid disease (AITD), including Hashimoto's thyroiditis (HT), but naturally occurring TPOAb are also detectable in healthy, euthyroid individuals. In AITD, circulating TPOAb react mainly with two immunodominant regions (IDR), IDR-A and IDR-B. The present study was undertaken in order to compare the epitope recognition pattern of TPOAb in HT patients and healthy subjects.

AB - Thyroid peroxidase antibodies (TPOAb) are markers of autoimmune thyroid disease (AITD), including Hashimoto's thyroiditis (HT), but naturally occurring TPOAb are also detectable in healthy, euthyroid individuals. In AITD, circulating TPOAb react mainly with two immunodominant regions (IDR), IDR-A and IDR-B. The present study was undertaken in order to compare the epitope recognition pattern of TPOAb in HT patients and healthy subjects.

U2 - 10.1111/j.1365-2265.2008.03245.x

DO - 10.1111/j.1365-2265.2008.03245.x

M3 - Journal article

C2 - 18363888

SN - 0300-0664

VL - 69

SP - 664

EP - 668

JO - Clinical Endocrinology

JF - Clinical Endocrinology

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ER -

Epitope recognition patterns of thyroid peroxidase autoantibodies in healthy individuals and patients with Hashimoto's thyroiditis*

Abstract

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