Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Identification of new genetic susceptibility Loci for breast cancer through consideration of gene-environment interactions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gynaecological cancer leads to long-term sick leave and permanently reduced working ability years after diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prevalence, incidence, and natural history of HPV infection in adult women ages 24 to 45 participating in a vaccine trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Ernest K Amankwah
  • Hui-Yi Lin
  • Jonathan P Tyrer
  • Kate Lawrenson
  • Joe Dennis
  • Ganna Chornokur
  • Katja K H Aben
  • Hoda Anton-Culver
  • Natalia Antonenkova
  • Fiona Bruinsma
  • Elisa V Bandera
  • Yukie T Bean
  • Matthias W Beckmann
  • Maria Bisogna
  • Line Bjorge
  • Natalia Bogdanova
  • Louise A Brinton
  • Angela Brooks-Wilson
  • Clareann H Bunker
  • Ralf Butzow
  • Ian G Campbell
  • Karen Carty
  • Zhihua Chen
  • Y Ann Chen
  • Jenny Chang-Claude
  • Linda S Cook
  • Daniel W Cramer
  • Julie M Cunningham
  • Cezary Cybulski
  • Agnieszka Dansonka-Mieszkowska
  • Andreas du Bois
  • Evelyn Despierre
  • Ed Dicks
  • Jennifer A Doherty
  • Thilo Dörk
  • Matthias Dürst
  • Douglas F Easton
  • Diana M Eccles
  • Robert P Edwards
  • Arif B Ekici
  • Peter A Fasching
  • Brooke L Fridley
  • Yu-Tang Gao
  • Aleksandra Gentry-Maharaj
  • Graham G Giles
  • Claus K Hogdall
  • Estrid Hogdall
  • Susanne K Kjaer
  • Lene Lundvall
  • Lotte Thomsen
  • Georgia Chenevix-Trench on behalf of the AOCS management group
Vis graf over relationer

Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value <0.05 and a false discovery rate (FDR) <0.2 were considered statistically significant. In the larger dataset, GPC6/GPC5 rs17702471 was associated with the endometrioid subtype among Caucasians (odds ratio (OR) = 1.16, 95% CI = 1.07-1.25, P = 0.0003, FDR = 0.19), whereas F8 rs7053448 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), F8 rs7058826 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), and CAPN13 rs1983383 (OR = 0.79, 95% CI = 0.69-0.90, P = 0.0005, FDR = 0.12) were associated with combined invasive EOC among Asians. In silico functional analyses revealed that GPC6/GPC5 rs17702471 coincided with DNA regulatory elements. These results suggest that EMT gene variants do not appear to play a significant role in the susceptibility to EOC.

OriginalsprogEngelsk
TidsskriftGenetic Epidemiology
Vol/bind39
Udgave nummer8
Sider (fra-til)689-697
ISSN0741-0395
DOI
StatusUdgivet - 24 sep. 2015

ID: 45866559