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Region Hovedstaden - en del af Københavns Universitetshospital
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Epidermal T cell subsets-Effect of age and antigen exposure in humans and mice

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DOI

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BACKGROUND: Epidermal T cells play a central role in immune surveillance and in inflammatory skin diseases. Major differences in the epidermal T cell composition are found between adult humans and antigen-inexperienced laboratory mice. Whether this is due to inborn species differences, to different environmental exposures, or a combination of the two is a matter of debate.

OBJECTIVES: To investigate the role of age and exposure to antigens on epidermal T cell subsets in human and mouse skin.

METHODS: We isolated T cells from the epidermis from 19 infants and 26 adults, and determined the frequency of CD4+ and CD8+ αβ T cells and γδ T cells by flow cytometry. In addition, we determined the epidermal T cell composition in antigen-inexperienced and antigen-experienced mice.

RESULTS: We found that humans are born with very few epidermal T cells. The number increases and the composition changes with age. In antigen-inexperienced mice, the epidermal T cell composition is unaffected by age, but it is dramatically affected by antigen exposure.

CONCLUSION: Taken together, we show that antigen exposure, as opposed to age, is the major factor determining the composition of epidermal T cells, suggesting that the skin of antigen-experienced mice better reflects the immunological conditions in human skin.

OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind84
Udgave nummer6
Sider (fra-til)375-384
Antal sider10
ISSN0105-1873
DOI
StatusUdgivet - jun. 2021

ID: 65571199