Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia

Tavs Qvist; Marita Gilljam; Bodil Jönsson; David Taylor-Robinson; Søren Jensen-Fangel; Mikala Wang; Anita Svahn; Karsten Kötz; Lennart Hansson; Annika Hollsing; Christine R Hansen; Pål L Finstad; Tanja Pressler; Niels Høiby; Terese L Katzenstein; Scandinavian Cystic Fibrosis Study Consortium (SCFSC); Kim Gjerum Nielsen

doi:10.1016/j.jcf.2014.08.002

Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia

Tavs Qvist, Marita Gilljam, Bodil Jönsson, David Taylor-Robinson, Søren Jensen-Fangel, Mikala Wang, Anita Svahn, Karsten Kötz, Lennart Hansson, Annika Hollsing, Christine R Hansen, Pål L Finstad, Tanja Pressler, Niels Høiby, Terese L Katzenstein, Scandinavian Cystic Fibrosis Study Consortium (SCFSC), Kim Gjerum Nielsen (Medlem af forfattergruppering)

101 Citationer (Scopus)

Abstract

BACKGROUND: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described.

METHODS: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics.

RESULTS: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died.

CONCLUSION: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome.

Originalsprog	Engelsk
Tidsskrift	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Vol/bind	14
Udgave nummer	1
Sider (fra-til)	46-52
Antal sider	7
ISSN	1569-1993
DOI	https://doi.org/10.1016/j.jcf.2014.08.002
Status	Udgivet - jan. 2015

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10.1016/j.jcf.2014.08.002

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Qvist, T., Gilljam, M., Jönsson, B., Taylor-Robinson, D., Jensen-Fangel, S., Wang, M., Svahn, A., Kötz, K., Hansson, L., Hollsing, A., Hansen, C. R., Finstad, P. L., Pressler, T., Høiby, N., Katzenstein, T. L., Scandinavian Cystic Fibrosis Study Consortium (SCFSC), & Nielsen, K. G. (2015). Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 14(1), 46-52. https://doi.org/10.1016/j.jcf.2014.08.002

Qvist, T, Gilljam, M, Jönsson, B, Taylor-Robinson, D, Jensen-Fangel, S, Wang, M, Svahn, A, Kötz, K, Hansson, L, Hollsing, A, Hansen, CR, Finstad, PL, Pressler, T , Høiby, N , Katzenstein, TL, Scandinavian Cystic Fibrosis Study Consortium (SCFSC) & Nielsen, KG 2015, 'Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, bind 14, nr. 1, s. 46-52. https://doi.org/10.1016/j.jcf.2014.08.002

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title = "Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia",

abstract = "BACKGROUND: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described.METHODS: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics.RESULTS: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died.CONCLUSION: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome.",

author = "Tavs Qvist and Marita Gilljam and Bodil J{\"o}nsson and David Taylor-Robinson and S{\o}ren Jensen-Fangel and Mikala Wang and Anita Svahn and Karsten K{\"o}tz and Lennart Hansson and Annika Hollsing and Hansen, {Christine R} and Finstad, {P{\aa}l L} and Tanja Pressler and Niels H{\o}iby and Katzenstein, {Terese L} and {Scandinavian Cystic Fibrosis Study Consortium (SCFSC)} and Nielsen, {Kim Gjerum}",

year = "2015",

month = jan,

doi = "10.1016/j.jcf.2014.08.002",

language = "English",

volume = "14",

pages = "46--52",

journal = "Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society",

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T1 - Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia

AU - Qvist, Tavs

AU - Gilljam, Marita

AU - Jönsson, Bodil

AU - Taylor-Robinson, David

AU - Jensen-Fangel, Søren

AU - Wang, Mikala

AU - Svahn, Anita

AU - Kötz, Karsten

AU - Hansson, Lennart

AU - Hollsing, Annika

AU - Hansen, Christine R

AU - Finstad, Pål L

AU - Pressler, Tanja

AU - Høiby, Niels

AU - Katzenstein, Terese L

AU - Scandinavian Cystic Fibrosis Study Consortium (SCFSC)

A2 - Nielsen, Kim Gjerum

PY - 2015/1

Y1 - 2015/1

N2 - BACKGROUND: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described.METHODS: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics.RESULTS: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died.CONCLUSION: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome.

AB - BACKGROUND: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described.METHODS: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics.RESULTS: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p<0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died.CONCLUSION: NTM are significant CF pathogens and are becoming more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome.

U2 - 10.1016/j.jcf.2014.08.002

DO - 10.1016/j.jcf.2014.08.002

M3 - Journal article

C2 - 25178871

SN - 1569-1993

VL - 14

SP - 46

EP - 52

JO - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

JF - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

IS - 1

ER -

Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia

Abstract

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