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Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

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@article{68f85965b28845f08f7b40aeec091227,
title = "Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes",
abstract = "The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11{\%} (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e' lat ) [-0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [-0.02 (0.01), P = 0.001] and lateral E/e' lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT (P = 0.75) or EAT (P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.",
keywords = "cardiac adipose tissue, diastolic dysfunction, epicardial adipose tissue, pericardial adipose tissue, systolic dysfunction, type 2 diabetes",
author = "Christensen, {Regitse H} and Hansen, {Christian S} and {von Scholten}, {Bernt Johan} and Jensen, {Magnus T} and Pedersen, {Bente K} and Peter Schnohr and Tina Vilsb{\o}ll and Peter Rossing and J{\o}rgensen, {Peter G}",
note = "{\circledC} 2019 John Wiley & Sons Ltd.",
year = "2019",
month = "8",
day = "1",
doi = "10.1111/dom.13758",
language = "English",
volume = "21",
pages = "2006--2011",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

AU - Christensen, Regitse H

AU - Hansen, Christian S

AU - von Scholten, Bernt Johan

AU - Jensen, Magnus T

AU - Pedersen, Bente K

AU - Schnohr, Peter

AU - Vilsbøll, Tina

AU - Rossing, Peter

AU - Jørgensen, Peter G

N1 - © 2019 John Wiley & Sons Ltd.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11% (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e' lat ) [-0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [-0.02 (0.01), P = 0.001] and lateral E/e' lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT (P = 0.75) or EAT (P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.

AB - The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11% (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e' lat ) [-0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [-0.02 (0.01), P = 0.001] and lateral E/e' lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT (P = 0.75) or EAT (P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.

KW - cardiac adipose tissue

KW - diastolic dysfunction

KW - epicardial adipose tissue

KW - pericardial adipose tissue

KW - systolic dysfunction

KW - type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85066148305&partnerID=8YFLogxK

U2 - 10.1111/dom.13758

DO - 10.1111/dom.13758

M3 - Journal article

VL - 21

SP - 2006

EP - 2011

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 8

ER -

ID: 57192998