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Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

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@article{68f85965b28845f08f7b40aeec091227,
title = "Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes",
abstract = "The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D vs. controls had increased EAT (4.6±1.8 mm vs. 3.4±1.2 mm, p<0.0001) and PAT (6.3±2.8 mm vs. 5.3±2.4 mm, p<0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all p<0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain (beta coefficient (SE)) (0.11{\%} (0.04), p=0.002), while EAT was associated with reduced diastolic function by lateral e'(-0.31 (0.05) cm/s, p=0.001), E/A ratio (-0.02 (0.01), p=0.001), and lateral E/e' (0.36, (0.10), p<0.001). However, no interaction was found between diabetes status and PAT (p=0.75) or EAT (p=0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D vs. controls and associated with functional myocardial measures in T2D. This article is protected by copyright. All rights reserved.",
keywords = "cardiac adipose tissue, diastolic dysfunction, epicardial adipose tissue, pericardial adipose tissue, systolic dysfunction, type 2 diabetes",
author = "Christensen, {Regitse H} and Hansen, {Christian S} and {von Scholten}, {Bernt Johan} and Jensen, {Magnus T} and Pedersen, {Bente K} and Peter Schnohr and Tina Vilsb{\o}ll and Peter Rossing and J{\o}rgensen, {Peter G}",
note = "{\circledC} 2019 John Wiley & Sons Ltd.",
year = "2019",
month = "8",
doi = "10.1111/dom.13758",
language = "English",
volume = "21",
pages = "2006--2011",
journal = "Diabetes, Obesity and Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

AU - Christensen, Regitse H

AU - Hansen, Christian S

AU - von Scholten, Bernt Johan

AU - Jensen, Magnus T

AU - Pedersen, Bente K

AU - Schnohr, Peter

AU - Vilsbøll, Tina

AU - Rossing, Peter

AU - Jørgensen, Peter G

N1 - © 2019 John Wiley & Sons Ltd.

PY - 2019/8

Y1 - 2019/8

N2 - The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D vs. controls had increased EAT (4.6±1.8 mm vs. 3.4±1.2 mm, p<0.0001) and PAT (6.3±2.8 mm vs. 5.3±2.4 mm, p<0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all p<0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain (beta coefficient (SE)) (0.11% (0.04), p=0.002), while EAT was associated with reduced diastolic function by lateral e'(-0.31 (0.05) cm/s, p=0.001), E/A ratio (-0.02 (0.01), p=0.001), and lateral E/e' (0.36, (0.10), p<0.001). However, no interaction was found between diabetes status and PAT (p=0.75) or EAT (p=0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D vs. controls and associated with functional myocardial measures in T2D. This article is protected by copyright. All rights reserved.

AB - The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D vs. controls had increased EAT (4.6±1.8 mm vs. 3.4±1.2 mm, p<0.0001) and PAT (6.3±2.8 mm vs. 5.3±2.4 mm, p<0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all p<0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain (beta coefficient (SE)) (0.11% (0.04), p=0.002), while EAT was associated with reduced diastolic function by lateral e'(-0.31 (0.05) cm/s, p=0.001), E/A ratio (-0.02 (0.01), p=0.001), and lateral E/e' (0.36, (0.10), p<0.001). However, no interaction was found between diabetes status and PAT (p=0.75) or EAT (p=0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D vs. controls and associated with functional myocardial measures in T2D. This article is protected by copyright. All rights reserved.

KW - cardiac adipose tissue

KW - diastolic dysfunction

KW - epicardial adipose tissue

KW - pericardial adipose tissue

KW - systolic dysfunction

KW - type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85066148305&partnerID=8YFLogxK

U2 - 10.1111/dom.13758

DO - 10.1111/dom.13758

M3 - Journal article

VL - 21

SP - 2006

EP - 2011

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 8

ER -

ID: 57192998