Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Carotid-femoral pulse wave velocity is a risk marker for complications in persons with type 1 diabetes

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskning

  2. GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Mitigating risk of aldosterone in diabetic kidney disease

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Sedentary work and risk of venous thromboembolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age- and sex-matched non-diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11% (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e' lat ) [-0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [-0.02 (0.01), P = 0.001] and lateral E/e' lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT (P = 0.75) or EAT (P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.

TidsskriftDiabetes, Obesity and Metabolism
Udgave nummer8
Sider (fra-til)2006-2011
Antal sider6
StatusUdgivet - 1 aug. 2019

ID: 57192998