Enterotoxigenic Escherichia coli infections and diarrhea in a cohort of young children in Guinea-Bissau

Hans Steinsland, Palle Valentiner-Branth, Michael Perch, Francisco Dias, Thea K Fischer, Peter Aaby, Kåre Mølbak, Halvor Sommerfelt

Abstract

In an effort to describe the natural history of enterotoxigenic Escherichia coli (ETEC) infection and diarrhea, 200 children in Guinea-Bissau, West Africa, were followed up from birth until up to age 2 years with weekly stool specimen collection, regardless of whether the children had diarrhea. ETEC isolates were tested for the presence of the porcine and human heat-stable toxins (STp and STh), the heat-labile toxin (LT), and 18 of 21 known colonization factors (CFs). The rate of primary infections increased substantially after age 3 or 6 months (depending on the type of ETEC causing the infection). The pathogenicity of STh-containing ETEC was substantially higher than that of STp-containing ETEC, and STp and STh were associated with separate sets of CFs. Small epidemics were observed, mainly caused by STh-containing ETEC. The difference in epidemic propensity, CF association, and pathogenicity suggests that STh- and STp-containing ETEC represent 2 different groups of human ETEC. Vaccines should primarily target STh-containing ETEC.

OriginalsprogEngelsk
TidsskriftThe Journal of infectious diseases
Vol/bind186
Udgave nummer12
Sider (fra-til)1740-7
Antal sider8
ISSN0022-1899
DOI
StatusUdgivet - 15 dec. 2002
Udgivet eksterntJa

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