Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

Jesper A B Strickertsson, Claus Desler, Tomas Martin-Bertelsen, Ana Manuel Dantas Machado, Torkel Wadstrøm, Ole Winther, Lene Juel Rasmussen, Lennart Friis-Hansen

68 Citationer (Scopus)

Abstract

Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind8
Udgave nummer4
Sider (fra-til)e63147
ISSN1932-6203
DOI
StatusUdgivet - 2013

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