Enkeltcenteropgørelse af nyretransplanterede patienters nyrefunktion og immunsuppressive behandling

Anne Mette Frederiksen, Jesper Melchior Hansen, Bettina Ewers, Ane Gasbjerg, Peter Marckmann

1 Citationer (Scopus)

Abstract

INTRODUCTION: The number of kidney-transplanted patients is growing. This report describes the age, sex distribution, kidney function, graft age, and immunosuppressive drugs of kidney-transplanted patients followed at the outpatient clinic of the nephrology department at Copenhagen University Hospital, Herlev, Denmark.

MATERIALS AND METHODS: Cross-sectional study of all living kidney-transplanted patients with a functioning graft followed at Copenhagen University Hospital, Herlev (n=241). Data were extracted from patient records during November 2005-March 2006.

RESULTS: The sex distribution (131 males, 110 females) was equal. The average patient age was 52 years (SD 12), the average glomerular filtration rate 43 ml/min/1.73 m2 (range 6-114 ml/min/1.73 m2), and the average graft age was 8.3 years (range 0-28 years). Hyperparathyroidism was highly prevalent (64%). The majority of patients (74%) were treated with triple-drug immunosuppression, in most cases (46%) with the combination prednisolone-ciclosporine-azathioprine. During recent years, azathioprine has been increasingly replaced by mycophenolate mofetil.

CONCLUSIONS: The majority of kidney-transplanted patients with a functioning graft have sufficient kidney function to keep the patients free of uremic symptoms. Hyperparathyroidism is frequent. The immunosuppressive regimens used for kidney-transplanted patients are currently changing.

Bidragets oversatte titelKidney function and immunosuppression of kidney-transplanted patients
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind170
Udgave nummer19
Sider (fra-til)1658-62
Antal sider5
ISSN0041-5782
StatusUdgivet - 5 maj 2008

Emneord

  • Adult
  • Azathioprine
  • Cross-Sectional Studies
  • Cyclosporine
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Humans
  • Hyperparathyroidism, Secondary
  • Immunosuppressive Agents
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Prednisolone
  • Treatment Outcome

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