Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteins

Claus Henrik Nielsen, Premalatha Balachandran, Ole Christensen, Nirmal D Pugh, Hemlata Tamta, Kenneth J Sufka, Xiangmei Wu, Anette Walsted, Michelle Schjørring-Thyssen, Christian Enevold, David S Pasco

    48 Citationer (Scopus)

    Abstract

    Immulina®, a commercial extract of Arthrospira (Spirulina) platensis is a potent activator of THP-1 monocytes and CD4+ T cells IN VITRO and enhances several immunological functions in mice. We further characterized Immulina® by determining that Braun-type lipoproteins are responsible for a major portion of the IN VITRO monocyte activation exhibited by this material. In order to understand the effect of Immulina® on NK cell activity, a pilot study was conducted on ten healthy North American individuals who supplemented their diet with Immulina® (400 mg/day) for seven days. We observed a 40 % average increase in the killing of K562 tumor cells by NK cells (p 
    OriginalsprogEngelsk
    TidsskriftPlanta Medica
    Vol/bind76
    Udgave nummer16
    Sider (fra-til)1802-8
    Antal sider7
    ISSN0032-0943
    DOI
    StatusUdgivet - 1 nov. 2010

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