Enhanced uptake and photoactivation of topical methyl aminolevulinate after fractional CO2 laser pretreatment

M Haedersdal, J Katsnelson, F H Sakamoto, W A Farinelli, A G Doukas, J Tam, R R Anderson

99 Citationer (Scopus)

Abstract

Photodynamic therapy (PDT) of thick skin lesions is limited by topical drug uptake. Ablative fractional resurfacing (AFR) creates vertical channels that may facilitate topical PDT drug penetration and improve PDT-response in deep skin layers. The purpose of this study was to evaluate whether pre-treating the skin with AFR before topically applied methyl aminolevulinate (MAL) could enable a deep PDT-response.
OriginalsprogEngelsk
TidsskriftLasers in Surgery and Medicine
Vol/bind43
Udgave nummer8
Sider (fra-til)804-13
Antal sider10
ISSN0196-8092
DOI
StatusUdgivet - 2011

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