Endogenous melatonin and oxidatively damaged guanine in DNA

Zoreh Davanipour, Henrik E Poulsen, Allan Weimann, Eugene Sobel

27 Citationer (Scopus)

Abstract

A significant body of literature indicates that melatonin, a hormone primarily produced nocturnally by the pineal gland, is an important scavenger of hydroxyl radicals and other reactive oxygen species. Melatonin may also lower the rate of DNA base damage resulting from hydroxyl radical attack and increase the rate of repair of that damage. This paper reports the results of a study relating the level of overnight melatonin production to the overnight excretion of the two primary urinary metabolites of the repair of oxidatively damaged guanine in DNA.
OriginalsprogEngelsk
TidsskriftB M C Endocrine Disorders
Vol/bind9
Sider (fra-til)22
ISSN1472-6823
DOI
StatusUdgivet - 1 jan. 2009

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