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Region Hovedstaden - en del af Københavns Universitetshospital
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ENDO-ERN expert opinion on the differential diagnosis of pubertal delay

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  • Luca Persani
  • Marco Bonomi
  • Martine Cools
  • Mehul Dattani
  • Leo Dunkel
  • Claus H Gravholt
  • Anders Juul
Vis graf over relationer

The differential diagnoses of pubertal delay include hypergonadotropic hypogonadism and congenital hypogonadotropic hypogonadism (CHH), as well as constitutional delay of growth and puberty (CDGP). Distinguishing between CDGP and CHH may be challenging, and the scientific community has been struggling to develop diagnostic tests that allow an accurate differential diagnosis. Indeed, an adequate and timely management is critical in order to enable optimal clinical and psychosocial outcomes of the different forms of pubertal delays. In this review, we provide an updated insight on the differential diagnoses of pubertal delay, including the available tests, their meanings and accuracy, as well as some clues to effectively orientate towards either constitutional pubertal delay or pathologic CHH and hypergonadotropic hypogonadism.

OriginalsprogEngelsk
TidsskriftEndocrine
Vol/bind71
Udgave nummer3
Sider (fra-til)681-688
Antal sider8
ISSN1355-008X
DOI
StatusUdgivet - mar. 2021

ID: 63790504