Enantiomer separation of 7-des-methyl-ormeloxifene using sulfated beta-cyclodextrin in countercurrent chromatography

null Breinholt; null Lehmann; Annemarie Reinhardt Varming

doi:10.1002/(SICI)1520-636X(1999)11:10<768::AID-CHIR5>3.0.CO;2-E

Enantiomer separation of 7-des-methyl-ormeloxifene using sulfated beta-cyclodextrin in countercurrent chromatography

Breinholt, Lehmann, Annemarie Reinhardt Varming

24 Citationer (Scopus)

Abstract

The enantiomers of 7-des-methyl-ormeloxifene were separated by countercurrent chromatography (CCC) using sulfated beta-cyclodextrin as chiral selector, representing the first reported successful application of a cyclodextrin derivative in CCC-based resolutions. The choice of chiral selector relies on extreme separation factors observed in chiral capillary electrophoresis, and suitable CCC conditions were developed employing an analytical toroidal coil countercurrent chromatograph. Preparative separation of the enantiomers was performed using a conventional, preparative CCC-instrument. Copyright 1999 Wiley-Liss, Inc.

Originalsprog	Engelsk
Tidsskrift	Chirality
Vol/bind	11
Udgave nummer	10
Sider (fra-til)	768-71
Antal sider	4
ISSN	0899-0042
DOI	https://doi.org/10.1002/(SICI)1520-636X(1999)11:10<768::AID-CHIR5>3.0.CO;2-E
Status	Udgivet - 1999
Udgivet eksternt	Ja

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10.1002/(SICI)1520-636X(1999)11:10<768::AID-CHIR5>3.0.CO;2-E

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title = "Enantiomer separation of 7-des-methyl-ormeloxifene using sulfated beta-cyclodextrin in countercurrent chromatography",

abstract = "The enantiomers of 7-des-methyl-ormeloxifene were separated by countercurrent chromatography (CCC) using sulfated beta-cyclodextrin as chiral selector, representing the first reported successful application of a cyclodextrin derivative in CCC-based resolutions. The choice of chiral selector relies on extreme separation factors observed in chiral capillary electrophoresis, and suitable CCC conditions were developed employing an analytical toroidal coil countercurrent chromatograph. Preparative separation of the enantiomers was performed using a conventional, preparative CCC-instrument. Copyright 1999 Wiley-Liss, Inc.",

keywords = "Journal Article",

author = "Breinholt and Lehmann and Varming, {Annemarie Reinhardt}",

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T1 - Enantiomer separation of 7-des-methyl-ormeloxifene using sulfated beta-cyclodextrin in countercurrent chromatography

AU - Breinholt, null

AU - Lehmann, null

AU - Varming, Annemarie Reinhardt

PY - 1999

Y1 - 1999

N2 - The enantiomers of 7-des-methyl-ormeloxifene were separated by countercurrent chromatography (CCC) using sulfated beta-cyclodextrin as chiral selector, representing the first reported successful application of a cyclodextrin derivative in CCC-based resolutions. The choice of chiral selector relies on extreme separation factors observed in chiral capillary electrophoresis, and suitable CCC conditions were developed employing an analytical toroidal coil countercurrent chromatograph. Preparative separation of the enantiomers was performed using a conventional, preparative CCC-instrument. Copyright 1999 Wiley-Liss, Inc.

AB - The enantiomers of 7-des-methyl-ormeloxifene were separated by countercurrent chromatography (CCC) using sulfated beta-cyclodextrin as chiral selector, representing the first reported successful application of a cyclodextrin derivative in CCC-based resolutions. The choice of chiral selector relies on extreme separation factors observed in chiral capillary electrophoresis, and suitable CCC conditions were developed employing an analytical toroidal coil countercurrent chromatograph. Preparative separation of the enantiomers was performed using a conventional, preparative CCC-instrument. Copyright 1999 Wiley-Liss, Inc.

KW - Journal Article

U2 - 10.1002/(SICI)1520-636X(1999)11:10<768::AID-CHIR5>3.0.CO;2-E

DO - 10.1002/(SICI)1520-636X(1999)11:10<768::AID-CHIR5>3.0.CO;2-E

M3 - Journal article

C2 - 10561706

SN - 0899-0042

VL - 11

SP - 768

EP - 771

JO - Chirality

JF - Chirality

IS - 10

ER -

Enantiomer separation of 7-des-methyl-ormeloxifene using sulfated beta-cyclodextrin in countercurrent chromatography

Abstract

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