Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

Lesley Wood; Matthias Egger; Lise Lotte Gluud; Kenneth F Schulz; Peter Jüni; Douglas G Altman; Christian Gluud; Richard M Martin; Anthony J G Wood; Jonathan A C Sterne

doi:10.1136/bmj.39465.451748.AD

Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

Lesley Wood, Matthias Egger, Lise Lotte Gluud, Kenneth F Schulz, Peter Jüni, Douglas G Altman, Christian Gluud, Richard M Martin, Anthony J G Wood, Jonathan A C Sterne

Copenhagen Trial Unit Rigshospitalet

2039 Citationer (Scopus)

Abstract

To examine whether the association of inadequate or unclear allocation concealment and lack of blinding with biased estimates of intervention effects varies with the nature of the intervention or outcome.

Originalsprog	Engelsk
Tidsskrift	BMJ
Vol/bind	336
Udgave nummer	7644
Sider (fra-til)	601-5
Antal sider	5
ISSN	1756-1833
DOI	https://doi.org/10.1136/bmj.39465.451748.AD
Status	Udgivet - 15 mar. 2008

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title = "Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study",

abstract = "To examine whether the association of inadequate or unclear allocation concealment and lack of blinding with biased estimates of intervention effects varies with the nature of the intervention or outcome.",

keywords = "Bias (Epidemiology), Double-Blind Method, Meta-Analysis as Topic, Odds Ratio, Randomized Controlled Trials as Topic",

author = "Lesley Wood and Matthias Egger and Gluud, \{Lise Lotte\} and Schulz, \{Kenneth F\} and Peter J{\"u}ni and Altman, \{Douglas G\} and Christian Gluud and Martin, \{Richard M\} and Wood, \{Anthony J G\} and Sterne, \{Jonathan A C\}",

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T2 - meta-epidemiological study

AU - Wood, Lesley

AU - Egger, Matthias

AU - Gluud, Lise Lotte

AU - Schulz, Kenneth F

AU - Jüni, Peter

AU - Altman, Douglas G

AU - Gluud, Christian

AU - Martin, Richard M

AU - Wood, Anthony J G

AU - Sterne, Jonathan A C

PY - 2008/3/15

Y1 - 2008/3/15

N2 - To examine whether the association of inadequate or unclear allocation concealment and lack of blinding with biased estimates of intervention effects varies with the nature of the intervention or outcome.

AB - To examine whether the association of inadequate or unclear allocation concealment and lack of blinding with biased estimates of intervention effects varies with the nature of the intervention or outcome.

KW - Bias (Epidemiology)

KW - Double-Blind Method

KW - Meta-Analysis as Topic

KW - Odds Ratio

KW - Randomized Controlled Trials as Topic

UR - https://www.scopus.com/pages/publications/40949113623

U2 - 10.1136/bmj.39465.451748.AD

DO - 10.1136/bmj.39465.451748.AD

M3 - Journal article

C2 - 18316340

SN - 1756-1833

VL - 336

SP - 601

EP - 605

JO - BMJ

JF - BMJ

IS - 7644

ER -

Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

Abstract

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