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Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART

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@article{c05ff873f4414a51b52c54926d31bffd,
title = "Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART",
abstract = "HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies.",
author = "Helene Mens and Lasse Fjordside and Jannik Fonager and Jan Gerstoft",
year = "2022",
month = jun,
day = "22",
doi = "10.3390/idr14040053",
language = "English",
volume = "14",
pages = "501--504",
journal = "Infectious disease reports",
issn = "2036-7430",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - Emergence of the G118R Pan-Integrase Resistance Mutation as a Result of Low Compliance to a Dolutegravir-Based cART

AU - Mens, Helene

AU - Fjordside, Lasse

AU - Fonager, Jannik

AU - Gerstoft, Jan

PY - 2022/6/22

Y1 - 2022/6/22

N2 - HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies.

AB - HIV-1 resistance towards integrase inhibitors is a potential threat of the success of HIV-1 combination treatment. G118R is a rare drug resistance mutation conferring pan-integrase resistance. Here, we describe the occurrence of G118R in a HIV-1 subtype-B-positive individual with major compliance problems, detected while the patient was on dolutegravir-based cART. We speculate the pre-selection of M184I/V aided the occurrence of G118R in this case, and discuss the robustness of dolutegravir-based therapies.

UR - http://www.scopus.com/inward/record.url?scp=85134366152&partnerID=8YFLogxK

U2 - 10.3390/idr14040053

DO - 10.3390/idr14040053

M3 - Journal article

C2 - 35893472

VL - 14

SP - 501

EP - 504

JO - Infectious disease reports

JF - Infectious disease reports

SN - 2036-7430

IS - 4

ER -

ID: 79929200