Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Emergence of circulating influenza A H3N2 viruses with genetic drift in the matrix gene: Be alert of false negative test results

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. APMIS 2022 focus issue on human microbiome in disease and pathology

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. Vancomycin-resistant Enterococcus faecium: should we screen on admission?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Vaginal microbiome following orally administered probiotic

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Vancomycin-resistant Enterococcus faecium: should we screen on admission?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. SARS-CoV-2 in asymptomatic Danish infants and their mothers from April 2020 to January 2022

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

Vis graf over relationer

In March 2022, we observed samples with a negative fluorescent signal (60.5%, n=43) for the influenza A matrix gene, and a stronger positive signal for subtype A(H3N2). Forty-three samples were positive in InfA (H3N2) (mean Cq 30.9, range 23.9-35.1) and 26 of the 43 samples were negative in InfA matrix (mean Cq 28.0, range 23.2-30.6). Our multiplex test is a laboratory developed four-target, four-color influenza A reverse-transcription PCR assay targeting the matrix gene, subtypes A(H3N2) and A(H1N1)pdm09. Several samples were negative when retested on commercial influenza Point-of-Care assays. As the matrix gene is a stand-alone target in most commercial diagnostic assays, we caution against false negative subtype A test results.

OriginalsprogEngelsk
TidsskriftAPMIS - Journal of Pathology, Microbiology and Immunology
Vol/bind130
Udgave nummer10
Sider (fra-til)612-617
Antal sider6
ISSN0903-4641
DOI
StatusUdgivet - okt. 2022

Bibliografisk note

This article is protected by copyright. All rights reserved.

ID: 79467337