Elevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin.

Bidragets oversatte titel: Elevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin.
31 Citationer (Scopus)

Abstract

Leptin, a peptide hormone produced mainly in fat cells, appears to be important for the regulation of metabolism, insulin secretion/sensitivity and body weight. Recently, elevated plasma leptin levels have been reported in patients with arterial hypertension. Because a change in circulating leptin concentrations in such patients could be caused by altered rates of production or disposal, or both, the aim of the present study was to identify regions of leptin overflow into the bloodstream and of leptin extraction. Patients with arterial hypertension (n=12) and normotensive controls (n=20) were studied during catheterization with elective blood sampling from different vascular beds (artery, and renal, hepatic, iliac and cubital veins). Plasma leptin was determined by a radioimmunoassay. Patients with hypertension had significantly elevated levels of circulating leptin (12.8 ng/l, compared with 4.1 ng/l in the controls; P
Bidragets oversatte titelElevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin.
OriginalsprogEngelsk
TidsskriftClinical Science
Vol/bind99
Udgave nummer6
Sider (fra-til)527-534
Antal sider8
ISSN0143-5221
StatusUdgivet - 2000

Citationsformater