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Elevated arterial lactate delays recovery of intracellular muscle pH after exercise

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@article{ce96ed62a956475d8815946a700db9fc,
title = "Elevated arterial lactate delays recovery of intracellular muscle pH after exercise",
abstract = "PURPOSE: We evaluated muscle proton elimination following similar exercise in the same muscle group following two exercise modalities.METHODS: Seven rowers performed handgrip or rowing exercise for ~ 5 min. The intracellular response of the wrist flexor muscles was evaluated by 31P nuclear magnetic resonance spectroscopy, while arterial and venous forearm blood was collected.RESULTS: Rowing and handgrip reduced intracellular pH to 6.3 ± 0.2 and 6.5 ± 0.1, arterial pH to 7.09 ± 0.03 and 7.40 ± 0.03 and venous pH to 6.95 ± 0.06 and 7.20 ± 0.04 (P < 0.05), respectively. Arterial and venous lactate increased to 17.5 ± 1.6 and 20.0 ± 1.6 mM after rowing while only to 2.6 ± 0.8 and 6.8 ± 0.8 mM after handgrip exercise. Arterio-venous concentration difference of bicarbonate and phosphocreatine recovery kinetics (T50% rowing 1.5 ± 0.7 min; handgrip 1.4 ± 1.0 min) was similar following the two exercise modalities. Yet, intramuscular pH recovery in the forearm flexor muscles was 3.5-fold slower after rowing than after handgrip exercise (T50% rowing of 2 ± 0.1 vs. 7 ± 0.3 min for handgrip).CONCLUSION: Rowing delays intracellular-pH recovery compared with handgrip exercise most likely because rowing, as opposed to handgrip exercise, increases systemic lactate concentration. Thus the intra-to-extra-cellular lactate gradient is small after rowing. Since this lactate gradient is the main driving force for intracellular lactate removal in muscle and, since pHi normalization is closely related to intracellular lactate removal, rowing results in a slower pHi recovery compared to handgrip exercise.",
keywords = "Adult, Exercise/physiology, Forearm/blood supply, Hand Strength/physiology, Humans, Hydrogen-Ion Concentration, Lactic Acid/blood, Magnetic Resonance Spectroscopy, Male, Muscle Contraction/physiology, Muscle, Skeletal/metabolism, Regional Blood Flow/physiology, Young Adult",
author = "Stefanos Volianitis and Secher, {N H} and Bj{\o}rn Quistorff",
year = "2018",
month = nov,
doi = "10.1007/s00421-018-3969-x",
language = "English",
volume = "118",
pages = "2429--2434",
journal = "European Journal of Applied Physiology and Occupational Physiology",
issn = "1439-6319",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - Elevated arterial lactate delays recovery of intracellular muscle pH after exercise

AU - Volianitis, Stefanos

AU - Secher, N H

AU - Quistorff, Bjørn

PY - 2018/11

Y1 - 2018/11

N2 - PURPOSE: We evaluated muscle proton elimination following similar exercise in the same muscle group following two exercise modalities.METHODS: Seven rowers performed handgrip or rowing exercise for ~ 5 min. The intracellular response of the wrist flexor muscles was evaluated by 31P nuclear magnetic resonance spectroscopy, while arterial and venous forearm blood was collected.RESULTS: Rowing and handgrip reduced intracellular pH to 6.3 ± 0.2 and 6.5 ± 0.1, arterial pH to 7.09 ± 0.03 and 7.40 ± 0.03 and venous pH to 6.95 ± 0.06 and 7.20 ± 0.04 (P < 0.05), respectively. Arterial and venous lactate increased to 17.5 ± 1.6 and 20.0 ± 1.6 mM after rowing while only to 2.6 ± 0.8 and 6.8 ± 0.8 mM after handgrip exercise. Arterio-venous concentration difference of bicarbonate and phosphocreatine recovery kinetics (T50% rowing 1.5 ± 0.7 min; handgrip 1.4 ± 1.0 min) was similar following the two exercise modalities. Yet, intramuscular pH recovery in the forearm flexor muscles was 3.5-fold slower after rowing than after handgrip exercise (T50% rowing of 2 ± 0.1 vs. 7 ± 0.3 min for handgrip).CONCLUSION: Rowing delays intracellular-pH recovery compared with handgrip exercise most likely because rowing, as opposed to handgrip exercise, increases systemic lactate concentration. Thus the intra-to-extra-cellular lactate gradient is small after rowing. Since this lactate gradient is the main driving force for intracellular lactate removal in muscle and, since pHi normalization is closely related to intracellular lactate removal, rowing results in a slower pHi recovery compared to handgrip exercise.

AB - PURPOSE: We evaluated muscle proton elimination following similar exercise in the same muscle group following two exercise modalities.METHODS: Seven rowers performed handgrip or rowing exercise for ~ 5 min. The intracellular response of the wrist flexor muscles was evaluated by 31P nuclear magnetic resonance spectroscopy, while arterial and venous forearm blood was collected.RESULTS: Rowing and handgrip reduced intracellular pH to 6.3 ± 0.2 and 6.5 ± 0.1, arterial pH to 7.09 ± 0.03 and 7.40 ± 0.03 and venous pH to 6.95 ± 0.06 and 7.20 ± 0.04 (P < 0.05), respectively. Arterial and venous lactate increased to 17.5 ± 1.6 and 20.0 ± 1.6 mM after rowing while only to 2.6 ± 0.8 and 6.8 ± 0.8 mM after handgrip exercise. Arterio-venous concentration difference of bicarbonate and phosphocreatine recovery kinetics (T50% rowing 1.5 ± 0.7 min; handgrip 1.4 ± 1.0 min) was similar following the two exercise modalities. Yet, intramuscular pH recovery in the forearm flexor muscles was 3.5-fold slower after rowing than after handgrip exercise (T50% rowing of 2 ± 0.1 vs. 7 ± 0.3 min for handgrip).CONCLUSION: Rowing delays intracellular-pH recovery compared with handgrip exercise most likely because rowing, as opposed to handgrip exercise, increases systemic lactate concentration. Thus the intra-to-extra-cellular lactate gradient is small after rowing. Since this lactate gradient is the main driving force for intracellular lactate removal in muscle and, since pHi normalization is closely related to intracellular lactate removal, rowing results in a slower pHi recovery compared to handgrip exercise.

KW - Adult

KW - Exercise/physiology

KW - Forearm/blood supply

KW - Hand Strength/physiology

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Lactic Acid/blood

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Muscle Contraction/physiology

KW - Muscle, Skeletal/metabolism

KW - Regional Blood Flow/physiology

KW - Young Adult

U2 - 10.1007/s00421-018-3969-x

DO - 10.1007/s00421-018-3969-x

M3 - Journal article

C2 - 30128851

VL - 118

SP - 2429

EP - 2434

JO - European Journal of Applied Physiology and Occupational Physiology

JF - European Journal of Applied Physiology and Occupational Physiology

SN - 1439-6319

IS - 11

ER -

ID: 56578932