Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin

G K Daugaard; J Petrera; W Trojaborg

doi:10.1111/j.1600-0404.1987.tb03551.x

Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin

G K Daugaard, J Petrera, W Trojaborg

48 Citationer (Scopus)

Abstract

We describe clinical and electrophysiological findings in 8 patients with tumors of germ cell origin before and after treatment with high-dose cisplatin (800-1400 mg) combined with etoposide and bleomycin. All patients developed clinical or electrophysiological signs, or both, of a peripheral sensory neuropathy. One had in addition clinical and electrophysiological signs of CNS involvement, and 2 had a central conduction defect revealed by auditory stimulation.

Originalsprog	Engelsk
Tidsskrift	Acta Neurologica Scandinavica
Vol/bind	76
Udgave nummer	2
Sider (fra-til)	86-93
Antal sider	8
ISSN	0001-6314
DOI	https://doi.org/10.1111/j.1600-0404.1987.tb03551.x
Status	Udgivet - aug. 1987
Udgivet eksternt	Ja

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10.1111/j.1600-0404.1987.tb03551.x

Citationsformater

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title = "Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin",

abstract = "We describe clinical and electrophysiological findings in 8 patients with tumors of germ cell origin before and after treatment with high-dose cisplatin (800-1400 mg) combined with etoposide and bleomycin. All patients developed clinical or electrophysiological signs, or both, of a peripheral sensory neuropathy. One had in addition clinical and electrophysiological signs of CNS involvement, and 2 had a central conduction defect revealed by auditory stimulation.",

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author = "Daugaard, {G K} and J Petrera and W Trojaborg",

year = "1987",

month = aug,

doi = "10.1111/j.1600-0404.1987.tb03551.x",

language = "English",

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AU - Daugaard, G K

AU - Petrera, J

AU - Trojaborg, W

PY - 1987/8

Y1 - 1987/8

N2 - We describe clinical and electrophysiological findings in 8 patients with tumors of germ cell origin before and after treatment with high-dose cisplatin (800-1400 mg) combined with etoposide and bleomycin. All patients developed clinical or electrophysiological signs, or both, of a peripheral sensory neuropathy. One had in addition clinical and electrophysiological signs of CNS involvement, and 2 had a central conduction defect revealed by auditory stimulation.

AB - We describe clinical and electrophysiological findings in 8 patients with tumors of germ cell origin before and after treatment with high-dose cisplatin (800-1400 mg) combined with etoposide and bleomycin. All patients developed clinical or electrophysiological signs, or both, of a peripheral sensory neuropathy. One had in addition clinical and electrophysiological signs of CNS involvement, and 2 had a central conduction defect revealed by auditory stimulation.

KW - Adolescent

KW - Adult

KW - Brain/drug effects

KW - Cisplatin/adverse effects

KW - Dose-Response Relationship, Drug

KW - Electroencephalography

KW - Evoked Potentials/drug effects

KW - Humans

KW - Male

KW - Middle Aged

KW - Neural Conduction/drug effects

KW - Peripheral Nerves/drug effects

KW - Reaction Time/drug effects

KW - Sensory Thresholds

KW - Testicular Neoplasms/drug therapy

KW - Touch/drug effects

U2 - 10.1111/j.1600-0404.1987.tb03551.x

DO - 10.1111/j.1600-0404.1987.tb03551.x

M3 - Journal article

C2 - 3673502

SN - 0001-6314

VL - 76

SP - 86

EP - 93

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

IS - 2

ER -

Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin

Abstract

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