Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Randomized trial of daily high-dose vitamin D3 in patients with RRMS receiving subcutaneous interferon β-1a

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Author response: Nationwide prevalence and incidence study of neuromyelitis optica spectrum disorder in Denmark

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  4. Fat oxidation is impaired during exercise in lipin-1 deficiency

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Secular trends in risk of stroke according to body mass index and blood pressure, 1976-2017

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A visual rating scale for cingulate island sign on 18F-FDG-PET to differentiate dementia with Lewy bodies and Alzheimer's disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Which Spreading Depolarizations Are Deleterious To Brain Tissue?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Diagnostic added value of electrical source imaging in presurgical evaluation of patients with epilepsy: A prospective study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy.

METHODS: We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic source imaging, and analysis of combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) and seizure onset zone (SOZ), we used intracranial recordings and for localization accuracy, outcome 1 year after operation.

RESULTS: We included 141 consecutive patients. EMSI showed localized epileptiform discharges in 94 patients (67%). Most of the epileptiform discharge clusters (72%) were identified by both modalities, 15% only by EEG, and 14% only by MEG. Agreement was substantial between inverse solutions and moderate between software packages. EMSI provided new information that changed the management plan in 34% of the patients, and these changes were useful in 80%. Depending on the method, EMSI had a concordance of 53% to 89% with IZ and 35% to 73% with SOZ. Localization accuracy of EMSI was between 44% and 57%, which was not significantly different from MRI (49%-76%) and PET (54%-85%). Combined EMSI achieved significantly higher odds ratio compared to electric source imaging and magnetic source imaging.

CONCLUSION: EMSI has accuracy similar to established imaging methods and provides clinically useful, new information in 34% of the patients.

CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that EMSI had a concordance of 53%-89% and 35%-73% (depending on analysis) for the localization of epileptic focus as compared with intracranial recordings-IZ and SOZ, respectively.

OriginalsprogEngelsk
TidsskriftNeurology
Vol/bind92
Udgave nummer6
Sider (fra-til)e576-e586
ISSN0028-3878
DOI
StatusUdgivet - 2019

ID: 56115542