Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression

Miklos Argyelan*, Zhi-De Deng, Olga Therese Ousdal, Leif Oltedal, Brian Angulo, Mate Baradits, Andrew J Spitzberg, Ute Kessler, Alexander Sartorius, Annemiek Dols, Katherine L Narr, Randall Espinoza, Jeroen A van Waarde, Indira Tendolkar, Philip van Eijndhoven, Guido A van Wingen, Akihiro Takamiya, Taishiro Kishimoto, Martin B Jorgensen, Anders JorgensenOlaf B Paulson, Antoine Yrondi, Patrice Péran, Carles Soriano-Mas, Narcis Cardoner, Marta Cano, Linda van Diermen, Didier Schrijvers, Jean-Baptiste Belge, Louise Emsell, Filip Bouckaert, Mathieu Vandenbulcke, Maximilian Kiebs, René Hurlemann, Peter Cr Mulders, Ronny Redlich, Udo Dannlowski, Kavakbasi Erhan, Michael D Kritzer, Kristen K Ellard, Joan A Camprodon, Georgios Petrides, Anil K Malhotra, Christopher C Abbott

*Corresponding author af dette arbejde
2 Citationer (Scopus)

Abstract

Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = -2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.

OriginalsprogEngelsk
TidsskriftMolecular Psychiatry
ISSN1359-4184
DOI
StatusE-pub ahead of print - 20 nov. 2023

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