Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression

Zhi-De Deng, Olga Theresa Ousdal, Leif Oltedal, Brian Angulo, Mate Baradits, Andrew Spitzberg, Ute Kessler, Alexander Sartorius, Annemiek Dols, Katherine Narr, Randall Espinoza, Jeroen Van Waarde, Indira Tendolkar, Philip van Eijndhoven, Guido van Wingen, Akihiro Takamiya, Taishiro Kishimoto, Martin Jorgensen, Anders Jorgensen, Olaf PaulsonAntoine Yrondi, Patrice Peran, Carles Soriano-Mas, Narcís Cardoner, Marta Cano, Linda van Diermen, Didier Schrijvers, Jean-Baptiste Belge, Louise Emsell, Filip Bouckaert, Mathieu Vandenbulcke, Maximilian Kiebs, Rene Hurlemann, Peter Mulders, Ronny Redlich, Udo Dannlowski, Erhan Kavakbasi, Michael Kritzer, Kristen Ellard, Joan Camprodon, Georgios Petrides, Anil Maholtra, Christopher Abbott, Miklos Argyelan


Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this common causal network (CCN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis (Principal Component Analysis, PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CCN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CCN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes. This evidence further supports that treatment interventions converge on a CCN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.

StatusUdgivet - 1 jun. 2023
NavnResearch Square


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