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Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections

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Alatraktchi, Fatima AlZahra'a ; Johansen, Helle Krogh ; Molin, Søren ; Svendsen, Winnie Edith. / Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections. I: Nanomedicine (London, England). 2016 ; Bind 11, Nr. 16. s. 2185-95.

Bibtex

@article{b60a68879313435c88dca8817e81fea2,
title = "Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections",
abstract = "AIM: Pseudomonas aeruginosa is a pathogen that is prevalent in serious infections in compromised patients worldwide. A unique virulence factor of this bacterium is the redox-active molecule pyocyanin, which is a potential biomarker for the identification of P. aeruginosa infections. Here we report a direct, selective and rapid detection technique of pyocyanin.MATERIALS & METHODS: Pyocyanin was detected by amperometry at a relatively high potential where the pyocyanin signal was unaffected by background contributions.RESULTS & CONCLUSION: Pyocyanin was detected at concentrations down to 125 nM in a 50 µM mixture of interfering compounds with a reproducibility of r(2) = 0.999 (n = 5) within 200 s. The results document a step toward a point-of-care technique for diagnosis of P. aeruginosa infections.",
keywords = "Journal Article",
author = "Alatraktchi, {Fatima AlZahra'a} and Johansen, {Helle Krogh} and S{\o}ren Molin and Svendsen, {Winnie Edith}",
year = "2016",
month = "8",
doi = "10.2217/nnm-2016-0155",
language = "English",
volume = "11",
pages = "2185--95",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine Ltd.",
number = "16",

}

RIS

TY - JOUR

T1 - Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections

AU - Alatraktchi, Fatima AlZahra'a

AU - Johansen, Helle Krogh

AU - Molin, Søren

AU - Svendsen, Winnie Edith

PY - 2016/8

Y1 - 2016/8

N2 - AIM: Pseudomonas aeruginosa is a pathogen that is prevalent in serious infections in compromised patients worldwide. A unique virulence factor of this bacterium is the redox-active molecule pyocyanin, which is a potential biomarker for the identification of P. aeruginosa infections. Here we report a direct, selective and rapid detection technique of pyocyanin.MATERIALS & METHODS: Pyocyanin was detected by amperometry at a relatively high potential where the pyocyanin signal was unaffected by background contributions.RESULTS & CONCLUSION: Pyocyanin was detected at concentrations down to 125 nM in a 50 µM mixture of interfering compounds with a reproducibility of r(2) = 0.999 (n = 5) within 200 s. The results document a step toward a point-of-care technique for diagnosis of P. aeruginosa infections.

AB - AIM: Pseudomonas aeruginosa is a pathogen that is prevalent in serious infections in compromised patients worldwide. A unique virulence factor of this bacterium is the redox-active molecule pyocyanin, which is a potential biomarker for the identification of P. aeruginosa infections. Here we report a direct, selective and rapid detection technique of pyocyanin.MATERIALS & METHODS: Pyocyanin was detected by amperometry at a relatively high potential where the pyocyanin signal was unaffected by background contributions.RESULTS & CONCLUSION: Pyocyanin was detected at concentrations down to 125 nM in a 50 µM mixture of interfering compounds with a reproducibility of r(2) = 0.999 (n = 5) within 200 s. The results document a step toward a point-of-care technique for diagnosis of P. aeruginosa infections.

KW - Journal Article

U2 - 10.2217/nnm-2016-0155

DO - 10.2217/nnm-2016-0155

M3 - Journal article

VL - 11

SP - 2185

EP - 2195

JO - Nanomedicine

JF - Nanomedicine

SN - 1743-5889

IS - 16

ER -

ID: 49928578