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Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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AIM: Pseudomonas aeruginosa is a pathogen that is prevalent in serious infections in compromised patients worldwide. A unique virulence factor of this bacterium is the redox-active molecule pyocyanin, which is a potential biomarker for the identification of P. aeruginosa infections. Here we report a direct, selective and rapid detection technique of pyocyanin.

MATERIALS & METHODS: Pyocyanin was detected by amperometry at a relatively high potential where the pyocyanin signal was unaffected by background contributions.

RESULTS & CONCLUSION: Pyocyanin was detected at concentrations down to 125 nM in a 50 µM mixture of interfering compounds with a reproducibility of r(2) = 0.999 (n = 5) within 200 s. The results document a step toward a point-of-care technique for diagnosis of P. aeruginosa infections.

OriginalsprogEngelsk
TidsskriftNanomedicine (London, England)
Vol/bind11
Udgave nummer16
Sider (fra-til)2185-95
Antal sider11
ISSN1743-5889
DOI
StatusUdgivet - aug. 2016

ID: 49928578