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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Electro convulsive therapy: Modification of its effect on the autonomic nervous system using anti-cholinergic drugs

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  3. Interpreter-mediated psychotherapy with trauma-affected refugees – A retrospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A systematic review of blood-based serotonergic biomarker in Bulimia Nervosa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Socio-demographic and clinical risk factors of treatment-resistant depression: A Danish population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Clinical association to FKBP5 rs1360780 in patients with depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  5. Electroconvulsive therapy increases cortical thickness in depression

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Vis graf over relationer

The antidepressant efficacy of electroconvulsive therapy (ECT) is correlated to the quality of the seizure as measured by EEG but has also been linked to the magnitude of changes in hemodynamic variables. Muscarinic receptor antagonists are frequently used in the treatment, and are known to affect the hemodynamic response. We hypothesized that atropine and glycopyrrolate alter the hemodynamic and autonomic hormonal response to ECT. In a randomized, cross-over study design 23 patients received either atropine, glycopyrrolate or placebo before ECT. Hemodynamic variable, EEG and EMG, and blood adrenaline, noradrenaline and pancreatic polypeptide was determined. No geriatric patients were included. Hemodynamic changes with ECT can be divided into three phases: Drop in blood pressure and pulse rate in 1st post-stimulus phase was less when using 1 mg atropine. In 2nd post-stimulus phase atropine gave a higher systolic blood pressure. No differences were seen in hormone levels after ECT in the three interventions. A significant longer tonic clonic seizure was seen in the glycopyrrolate group and a tendency of the same was seen with atropine. The study found that the changes in hemodynamic variables induced by ECT can be altered by concomitant administration of muscarinic receptor antagonist.

OriginalsprogEngelsk
TidsskriftPsychiatry Research
Vol/bind271
Sider (fra-til)239-246
Antal sider8
ISSN0165-1781
DOI
StatusUdgivet - 23 nov. 2018

ID: 55757445