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Region Hovedstaden - en del af Københavns Universitetshospital
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Efficient high-resolution TMS mapping of the human motor cortex by nonlinear regression

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  1. Database of 25 validated coil models for electric field simulations for TMS

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  4. Validated TMS coil models for electric field simulations

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskning

  • Ole Numssen
  • Anna-Leah Zier
  • Axel Thielscher
  • Gesa Hartwigsen
  • Thomas R Knösche
  • Konstantin Weise
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Transcranial magnetic stimulation (TMS) is a powerful tool to investigate causal structure-function relationships in the human brain. However, a precise delineation of the effectively stimulated neuronal populations is notoriously impeded by the widespread and complex distribution of the induced electric field. Here, we propose a method that allows rapid and feasible cortical localization at the individual subject level. The functional relationship between electric field and behavioral effect is quantified by combining experimental data with numerically modeled fields to identify the cortical origin of the modulated effect. Motor evoked potentials (MEPs) from three finger muscles were recorded for a set of random stimulations around the primary motor area. All induced electric fields were nonlinearly regressed against the elicited MEPs to identify their cortical origin. We could distinguish cortical muscle representation with high spatial resolution and localized them primarily on the crowns and rims of the precentral gyrus. A post-hoc analysis revealed exponential convergence of the method with the number of stimulations, yielding a minimum of about 180 random stimulations to obtain stable results. Establishing a functional link between the modulated effect and the underlying mode of action, the induced electric field, is a fundamental step to fully exploit the potential of TMS. In contrast to previous approaches, the presented protocol is particularly easy to implement, fast to apply, and very robust due to the random coil positioning and therefore is suitable for practical and clinical applications.

OriginalsprogEngelsk
Artikelnummer118654
TidsskriftNeuroImage
Vol/bind245
Sider (fra-til)1-11
Antal sider11
ISSN1053-8119
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

Copyright © 2021. Published by Elsevier Inc.

ID: 68557525