Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. GLP-1 based therapies and disease course of inflammatory bowel disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Successful glucose lowering therapy triumphs in heart failure

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  3. Implementation of indicator condition guided HIV testing still lagging behind the evidence

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Criteria-based dispatch of emergency medical services in non-traumatic subarachnoid haemorrhage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Symptoms presented during emergency telephone calls for patients with spontaneous subarachnoid haemorrhage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nurses' Experiences and Perceptions of two Early Warning Score systems to Identify Patient Deterioration-A Focus Group Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Danish translation and linguistic validation of the multidimensional dyspnea profile

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Jesper D Gunst
  • Nina B Staerke
  • Marie H Pahus
  • Lena H Kristensen
  • Jacob Bodilsen
  • Nicolai Lohse
  • Lars S Dalgaard
  • Dorthe Brønnum
  • Ole Fröbert
  • Bo Hønge
  • Isik S Johansen
  • Ida Monrad
  • Christian Erikstrup
  • Regitze Rosendal
  • Emil Vilstrup
  • Theis Mariager
  • Dorthe G Bove
  • Rasmus Offersen
  • Shakil Shakar
  • Sara Cajander
  • Nis P Jørgensen
  • Sajitha S Sritharan
  • Peter Breining
  • Søren Jespersen
  • Klaus L Mortensen
  • Mads L Jensen
  • Lilian Kolte
  • Giacomo S Frattari
  • Carsten S Larsen
  • Merete Storgaard
  • Lars P Nielsen
  • Martin Tolstrup
  • Eva A Sædder
  • Lars J Østergaard
  • Hien T T Ngo
  • Morten H Jensen
  • Jesper F Højen
  • Mads Kjolby
  • Ole S Søgaard
Vis graf over relationer

Background: The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials.

Methods: We conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as ≥2 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load.

Findings: 137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group ( P = 0·31). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0·82 (95% confidence interval [CI], 0·24 to 2·79; P = 0·75). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0·22 log 10 copies/mL ( p <0·05) and -0·82 log 10 in the placebo group ( P <0·05).

Interpretation: Under this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001200-42.

OriginalsprogEngelsk
Artikelnummer100849
TidsskriftEClinicalMedicine
Vol/bind35
ISSN2589-5370
DOI
StatusUdgivet - maj 2021

ID: 65157655