Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis

P Vestergaard; N R Jorgensen; P Schwarz; Leif Mosekilde

doi:10.1007/s00198-007-0437-6

Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis

P Vestergaard, N R Jorgensen, P Schwarz, Leif Mosekilde

101 Citationer (Scopus)

Abstract

Fluoride has fallen into discredit due to the absence of an anti-fracture effect. However, in this meta-analysis, a fracture reducing potential was seen at low fluoride doses [<or =20 mg fluoride equivalents (152 mg monofluorophosphate/44 mg sodium fluoride)]: OR = 0.3, 95% CI: 0.1-0.9 for vertebral and OR = 0.5, 95% CI: 0.3-0.8 for non-vertebral fractures.

Originalsprog	Engelsk
Tidsskrift	Osteoporosis International
Vol/bind	19
Udgave nummer	3
Sider (fra-til)	257-68
Antal sider	12
ISSN	0937-941X
DOI	https://doi.org/10.1007/s00198-007-0437-6
Status	Udgivet - 2008

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10.1007/s00198-007-0437-6

Citationsformater

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title = "Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis",

abstract = "Fluoride has fallen into discredit due to the absence of an anti-fracture effect. However, in this meta-analysis, a fracture reducing potential was seen at low fluoride doses [<or =20 mg fluoride equivalents (152 mg monofluorophosphate/44 mg sodium fluoride)]: OR = 0.3, 95% CI: 0.1-0.9 for vertebral and OR = 0.5, 95% CI: 0.3-0.8 for non-vertebral fractures.",

keywords = "Bone Density, Fluorides, Fractures, Bone, Hip Joint, Humans, Randomized Controlled Trials as Topic, Spinal Fractures, Spine",

author = "P Vestergaard and Jorgensen, {N R} and P Schwarz and Leif Mosekilde",

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T1 - Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis

AU - Vestergaard, P

AU - Jorgensen, N R

AU - Schwarz, P

AU - Mosekilde, Leif

PY - 2008

Y1 - 2008

N2 - Fluoride has fallen into discredit due to the absence of an anti-fracture effect. However, in this meta-analysis, a fracture reducing potential was seen at low fluoride doses [<or =20 mg fluoride equivalents (152 mg monofluorophosphate/44 mg sodium fluoride)]: OR = 0.3, 95% CI: 0.1-0.9 for vertebral and OR = 0.5, 95% CI: 0.3-0.8 for non-vertebral fractures.

AB - Fluoride has fallen into discredit due to the absence of an anti-fracture effect. However, in this meta-analysis, a fracture reducing potential was seen at low fluoride doses [<or =20 mg fluoride equivalents (152 mg monofluorophosphate/44 mg sodium fluoride)]: OR = 0.3, 95% CI: 0.1-0.9 for vertebral and OR = 0.5, 95% CI: 0.3-0.8 for non-vertebral fractures.

KW - Bone Density

KW - Fluorides

KW - Fractures, Bone

KW - Hip Joint

KW - Humans

KW - Randomized Controlled Trials as Topic

KW - Spinal Fractures

KW - Spine

U2 - 10.1007/s00198-007-0437-6

DO - 10.1007/s00198-007-0437-6

M3 - Journal article

C2 - 17701094

SN - 0937-941X

VL - 19

SP - 257

EP - 268

JO - Osteoporosis International

JF - Osteoporosis International

IS - 3

ER -

Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis

Abstract

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