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Effects of thyrotropin-releasing hormone on regional cerebral blood flow in man

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@article{35895e71ed9b46b08b1d89f55854a062,
title = "Effects of thyrotropin-releasing hormone on regional cerebral blood flow in man",
abstract = "To assess the regional changes in cerebral blood flow, 10 healthy volunteers were given 400 micrograms thyrotropin-releasing hormone iv in a double-blind, randomized, cross-over study. Regional cerebral blood flow was determined simultaneously in two slices of the brain, using a single photon emission computerized tomograph and inhalation of 133Xe. Thyrotropin-releasing hormone caused a significant mean increase of 3.7{\%} (range -8.8-22.7) in blood flow in a region consistent with the left thalamus compared to placebo (3.2{\%} decrease). In 25 other regions no significant change was detected. The thalamic region has previously been shown to be a region especially affected by thyrotropin-releasing hormone in animal studies. The thyrotropin-releasing hormone injection was followed by a minor rise in systemic blood pressure, but not a rise that could affect the cerebral blood flow. The effect of thyrotropin-releasing hormone on the regional cerebral blood flow in the thalamic region was much lower compared to changes found in sedated animals given a hundredfold higher dose of thyrotropin-releasing hormone.",
keywords = "Adult, Blood Pressure, Cerebrovascular Circulation, Diastole, Humans, Male, Thyrotropin-Releasing Hormone",
author = "Oturai, {P S} and L Friberg and I Sam and H Perrild",
year = "1992",
month = "3",
language = "English",
volume = "126",
pages = "243--6",
journal = "Acta Endocrinology",
issn = "0001-5598",
publisher = "Periodica",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of thyrotropin-releasing hormone on regional cerebral blood flow in man

AU - Oturai, P S

AU - Friberg, L

AU - Sam, I

AU - Perrild, H

PY - 1992/3

Y1 - 1992/3

N2 - To assess the regional changes in cerebral blood flow, 10 healthy volunteers were given 400 micrograms thyrotropin-releasing hormone iv in a double-blind, randomized, cross-over study. Regional cerebral blood flow was determined simultaneously in two slices of the brain, using a single photon emission computerized tomograph and inhalation of 133Xe. Thyrotropin-releasing hormone caused a significant mean increase of 3.7% (range -8.8-22.7) in blood flow in a region consistent with the left thalamus compared to placebo (3.2% decrease). In 25 other regions no significant change was detected. The thalamic region has previously been shown to be a region especially affected by thyrotropin-releasing hormone in animal studies. The thyrotropin-releasing hormone injection was followed by a minor rise in systemic blood pressure, but not a rise that could affect the cerebral blood flow. The effect of thyrotropin-releasing hormone on the regional cerebral blood flow in the thalamic region was much lower compared to changes found in sedated animals given a hundredfold higher dose of thyrotropin-releasing hormone.

AB - To assess the regional changes in cerebral blood flow, 10 healthy volunteers were given 400 micrograms thyrotropin-releasing hormone iv in a double-blind, randomized, cross-over study. Regional cerebral blood flow was determined simultaneously in two slices of the brain, using a single photon emission computerized tomograph and inhalation of 133Xe. Thyrotropin-releasing hormone caused a significant mean increase of 3.7% (range -8.8-22.7) in blood flow in a region consistent with the left thalamus compared to placebo (3.2% decrease). In 25 other regions no significant change was detected. The thalamic region has previously been shown to be a region especially affected by thyrotropin-releasing hormone in animal studies. The thyrotropin-releasing hormone injection was followed by a minor rise in systemic blood pressure, but not a rise that could affect the cerebral blood flow. The effect of thyrotropin-releasing hormone on the regional cerebral blood flow in the thalamic region was much lower compared to changes found in sedated animals given a hundredfold higher dose of thyrotropin-releasing hormone.

KW - Adult

KW - Blood Pressure

KW - Cerebrovascular Circulation

KW - Diastole

KW - Humans

KW - Male

KW - Thyrotropin-Releasing Hormone

M3 - Journal article

VL - 126

SP - 243

EP - 246

JO - Acta Endocrinology

JF - Acta Endocrinology

SN - 0001-5598

IS - 3

ER -

ID: 44347573