Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats

K Mangano; N Y Sardesai; C Quattrocchi; E Mazzon; S Cuzzocrea; K Bendtzen; P L Meroni; J J Kim; F Nicoletti

doi:10.1038/bjp.2008.315

Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats

K Mangano, N Y Sardesai, C Quattrocchi, E Mazzon, S Cuzzocrea, K Bendtzen, P L Meroni, J J Kim, F Nicoletti

7 Citationer (Scopus)

Abstract

VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.

Originalsprog	Engelsk
Tidsskrift	British Journal of Pharmacology
Vol/bind	155
Udgave nummer	5
Sider (fra-til)	722-30
Antal sider	9
ISSN	0007-1188
DOI	https://doi.org/10.1038/bjp.2008.315
Status	Udgivet - 1 nov. 2008

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10.1038/bjp.2008.315

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abstract = "VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.",

author = "K Mangano and Sardesai, {N Y} and C Quattrocchi and E Mazzon and S Cuzzocrea and K Bendtzen and Meroni, {P L} and Kim, {J J} and F Nicoletti",

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AU - Mangano, K

AU - Sardesai, N Y

AU - Quattrocchi, C

AU - Mazzon, E

AU - Cuzzocrea, S

AU - Bendtzen, K

AU - Meroni, P L

AU - Kim, J J

AU - Nicoletti, F

PY - 2008/11/1

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N2 - VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.

AB - VGX-1027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno-inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen-induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX-1027 on the development of endotoxin-induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.

U2 - 10.1038/bjp.2008.315

DO - 10.1038/bjp.2008.315

M3 - Journal article

C2 - 18776919

SN - 0007-1188

VL - 155

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JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

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ER -

Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats

Abstract

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