TY - JOUR
T1 - Effects of surgery on ischaemic mitral regurgitation
T2 - a prospective multicentre registry (SIMRAM registry)
AU - Lancellotti, Patrizio
AU - Donal, Erwan
AU - Cosyns, Bernard
AU - Van Camp, Guy
AU - Monin, Jean-Luc
AU - Brochet, Eric
AU - Berrebi, Alain
AU - Pibarot, Philippe
AU - Chauvel, Christophe
AU - Hassager, Christian
AU - Tumminello, Gabriele
AU - Tribouilloy, Christophe
AU - Lafitte, Stéphane
AU - Fraser, Alan G
AU - Derumeaux, Genevieve
AU - Athanassopoulos, George
AU - Bax, Jeroen
AU - Piérard, Luc A
PY - 2008/1
Y1 - 2008/1
N2 - AIMS: Functional ischaemic mitral regurgitation (IMR) is common in patients with ischaemic left ventricular dysfunction undergoing coronary artery bypass surgery. Although the presence of IMR negatively affects prognosis, the additional benefit of valve repair is debated, particularly with mild IMR at rest. Exercise echocardiography may help identify a subset of patients at higher risk of cardiovascular events by revealing the dynamic component of IMR.METHODS: A large prospective, multicentre, non-randomized registry is designed to evaluate the effects of surgery on IMR at rest and on its dynamic component at exercise (z). SIMRAM will enrol approximately 550 patients with IMR in up to 17 centres with clinical and exercise follow-up for 1 year. Three sets of outcomes will be prospectively assessed and several hypotheses will be tested including determinants of adverse outcome and progressive left ventricular remodeling, efficacy of treatment and role of ischaemia on the dynamic consequences of IMR. Enrolment began in November 2006 and is expected to end by early 2008.
AB - AIMS: Functional ischaemic mitral regurgitation (IMR) is common in patients with ischaemic left ventricular dysfunction undergoing coronary artery bypass surgery. Although the presence of IMR negatively affects prognosis, the additional benefit of valve repair is debated, particularly with mild IMR at rest. Exercise echocardiography may help identify a subset of patients at higher risk of cardiovascular events by revealing the dynamic component of IMR.METHODS: A large prospective, multicentre, non-randomized registry is designed to evaluate the effects of surgery on IMR at rest and on its dynamic component at exercise (z). SIMRAM will enrol approximately 550 patients with IMR in up to 17 centres with clinical and exercise follow-up for 1 year. Three sets of outcomes will be prospectively assessed and several hypotheses will be tested including determinants of adverse outcome and progressive left ventricular remodeling, efficacy of treatment and role of ischaemia on the dynamic consequences of IMR. Enrolment began in November 2006 and is expected to end by early 2008.
KW - Canada
KW - Coronary Artery Bypass
KW - Echocardiography, Doppler
KW - Europe
KW - Exercise Test
KW - Female
KW - Humans
KW - Male
KW - Mitral Valve Insufficiency/diagnostic imaging
KW - Myocardial Ischemia/diagnostic imaging
KW - Prospective Studies
KW - Registries
KW - Treatment Outcome
U2 - 10.1016/j.euje.2006.12.009
DO - 10.1016/j.euje.2006.12.009
M3 - Journal article
C2 - 17336589
SN - 1525-2167
VL - 9
SP - 26
EP - 30
JO - European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
JF - European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
IS - 1
ER -