Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

S C Jacobsen; C Brøns; Jette Bork-Jensen; Rasmus Ribel-Madsen; Bin Yang; E Lara; Elisabeth Hall; V Calvanese; E Nilsson; S W Jørgensen; S Mandrup; C Ling; Ingi A. Fernandez; M F Fraga; P Poulsen; A Vaag

doi:10.1007/s00125-012-2717-8

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

S C Jacobsen, C Brøns, Jette Bork-Jensen, Rasmus Ribel-Madsen, Bin Yang, E Lara, Elisabeth Hall, V Calvanese, E Nilsson, S W Jørgensen, S Mandrup, C Ling, Ingi A. Fernandez, M F Fraga, P Poulsen, A Vaag

172 Citationer (Scopus)

Abstract

Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	55
Udgave nummer	12
Sider (fra-til)	3341-9
Antal sider	9
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-012-2717-8
Status	Udgivet - 2012

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10.1007/s00125-012-2717-8

Citationsformater

Jacobsen, S. C., Brøns, C., Bork-Jensen, J., Ribel-Madsen, R., Yang, B., Lara, E., Hall, E., Calvanese, V., Nilsson, E., Jørgensen, S. W., Mandrup, S., Ling, C., Fernandez, I. A., Fraga, M. F., Poulsen, P., & Vaag, A. (2012). Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men. Diabetologia, 55(12), 3341-9. https://doi.org/10.1007/s00125-012-2717-8

Jacobsen, SC, Brøns, C, Bork-Jensen, J, Ribel-Madsen, R, Yang, B, Lara, E, Hall, E, Calvanese, V, Nilsson, E, Jørgensen, SW, Mandrup, S, Ling, C, Fernandez, IA, Fraga, MF, Poulsen, P & Vaag, A 2012, 'Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men', Diabetologia, bind 55, nr. 12, s. 3341-9. https://doi.org/10.1007/s00125-012-2717-8

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title = "Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men",

abstract = "Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.",

author = "Jacobsen, {S C} and C Br{\o}ns and Jette Bork-Jensen and Rasmus Ribel-Madsen and Bin Yang and E Lara and Elisabeth Hall and V Calvanese and E Nilsson and J{\o}rgensen, {S W} and S Mandrup and C Ling and Fernandez, {Ingi A.} and Fraga, {M F} and P Poulsen and A Vaag",

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doi = "10.1007/s00125-012-2717-8",

language = "English",

volume = "55",

pages = "3341--9",

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TY - JOUR

T1 - Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

AU - Jacobsen, S C

AU - Brøns, C

AU - Bork-Jensen, Jette

AU - Ribel-Madsen, Rasmus

AU - Yang, Bin

AU - Lara, E

AU - Hall, Elisabeth

AU - Calvanese, V

AU - Nilsson, E

AU - Jørgensen, S W

AU - Mandrup, S

AU - Ling, C

AU - Fernandez, Ingi A.

AU - Fraga, M F

AU - Poulsen, P

AU - Vaag, A

PY - 2012

Y1 - 2012

N2 - Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.

AB - Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle.

U2 - 10.1007/s00125-012-2717-8

DO - 10.1007/s00125-012-2717-8

M3 - Journal article

C2 - 22961225

SN - 0012-186X

VL - 55

SP - 3341

EP - 3349

JO - Diabetologia

JF - Diabetologia

IS - 12

ER -

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

Abstract

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