@article{1bb381722038421984b993d52bee64c8,
title = "Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects",
abstract = "Decreased levels of GH and total IGF-I have been reported in obesity. It has been hypothesized that increased free (biologically active) IGF-I levels generated from IGF-binding protein (IGFBP) protease activity could be the mechanism for the low GH release in dieting obese subjects. However, no published data exist on free IGF-I levels, acid labile subunit (ALS), or IGFBP protease activity in relation to GH release during a hypocaloric diet. The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1-4, and IGFBPs-1-3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD).",
keywords = "Adult, Body Mass Index, Body Weight, Caloric Restriction, Carrier Proteins, Diet, Reducing, Endopeptidases, Female, Glycoproteins, Human Growth Hormone, Humans, Insulin Resistance, Insulin-Like Growth Factor Binding Protein 2, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor Binding Protein 4, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor I, Leptin, Male, Obesity, Protein Denaturation, Thinness, Time Factors, Weight Loss",
author = "Rasmussen, {Michael H{\o}jby} and Anders Juul and Kjems, {Lise Lund} and Jannik Hilsted",
year = "2006",
doi = "10.1530/eje.1.02246",
language = "English",
volume = "155",
pages = "575--81",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd",
number = "4",
}