Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Stine Brinkløv Thomsen, Camilla Noelle Rathcke, Nils Bruun Jørgensen, Sten Madsbad, Henrik Vestergaard

12 Citationer (Scopus)

Abstract

Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values
OriginalsprogEngelsk
TidsskriftJournal of Obesity
Vol/bind2013
Sider (fra-til)361781
ISSN2090-0708
DOI
StatusUdgivet - 2014

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