Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Stine Brinkløv Thomsen; Camilla Noelle Rathcke; Nils Bruun Jørgensen; Sten Madsbad; Henrik Vestergaard

doi:10.1155/2013/361781

Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Stine Brinkløv Thomsen, Camilla Noelle Rathcke, Nils Bruun Jørgensen, Sten Madsbad, Henrik Vestergaard

Endokrinologisk Afdeling

14 Citationer (Scopus)

Abstract

Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values

Originalsprog	Engelsk
Tidsskrift	Journal of Obesity
Vol/bind	2013
Sider (fra-til)	361781
ISSN	2090-0708
DOI	https://doi.org/10.1155/2013/361781
Status	Udgivet - 2014

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10.1155/2013/361781

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Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects. / Thomsen, Stine Brinkløv; Rathcke, Camilla Noelle; Jørgensen, Nils Bruun et al.
I: Journal of Obesity, Bind 2013, 2014, s. 361781.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values ",

author = "Thomsen, {Stine Brinkl{\o}v} and Rathcke, {Camilla Noelle} and J{\o}rgensen, {Nils Bruun} and Sten Madsbad and Henrik Vestergaard",

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doi = "10.1155/2013/361781",

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T1 - Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

AU - Thomsen, Stine Brinkløv

AU - Rathcke, Camilla Noelle

AU - Jørgensen, Nils Bruun

AU - Madsbad, Sten

AU - Vestergaard, Henrik

PY - 2014

Y1 - 2014

N2 - Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values

AB - Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values

U2 - 10.1155/2013/361781

DO - 10.1155/2013/361781

M3 - Journal article

C2 - 24303210

SN - 2090-0708

VL - 2013

SP - 361781

JO - Journal of Obesity

JF - Journal of Obesity

ER -

Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Abstract

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