@article{8f5ffa3898e344d0ab58cf92b8afcfc8,
title = "Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia",
abstract = "Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.",
keywords = "AIDS-Related Opportunistic Infections, Adult, Aged, Bronchoalveolar Lavage Fluid, Cohort Studies, Dihydropteroate Synthase, Drug Resistance, Microbial, Genotype, HIV-1, Humans, Middle Aged, Pneumocystis, Pneumonia, Pneumocystis, Point Mutation, Polymerase Chain Reaction, Prognosis, Recurrence, Regression Analysis, Sulfamethoxazole, Survival Analysis",
author = "J Helweg-Larsen and Thomas Benfield and J Eugen-Olsen and Lundgren, {J D} and B Lundgren",
year = "1999",
doi = "10.1016/S0140-6736(99)03320-6",
language = "English",
volume = "354",
pages = "1347--51",
journal = "Lancet",
issn = "0140-6736",
publisher = "The/Lancet Publishing Group",
number = "9187",
}