Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease - protocol for a controlled, randomized double-blinded trial

Lærke Egefjord, Michael Gejl, Peter Arne Møller, Hans Brændgaard, Hanne Gottrup, Olga Antropova, Niels Møller, Henrik E Poulsen, Albert Gjedde, Birgitte Brock, Jørgen Rungby

71 Citationer (Scopus)

Abstract

Type 2 diabetes (DM-2) increases the risk of developing Alzheimer´s disease (AD), and patients with AD are more likely to develop DM-2. DM-2 and AD share some pathophysiological features. In AD, amyloid-β (Aβ) is accumulated as extracellular plaques in the gray matter of the brain, while in DM-2 islet amyloid polypeptide (IAPP) is accumulated in the pancreas. Premature cellular degeneration is seen in both diseases. Glucagon-like peptide-1 (GLP-1) reduces the amount of Aβ and improves cognition in animal studies. The present study tests the hypothesis that treatment with the long-acting GLP-1 receptor agonist liraglutide affects the accumulation of Aβ in patients with AD.
OriginalsprogEngelsk
TidsskriftDanish Medical Journal
Vol/bind59
Udgave nummer10
Sider (fra-til)A4519
StatusUdgivet - 2012

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