Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients

K V Hendriksen; Tonny Joran Jensen; P Oturai; B Feldt-Rasmussen

doi:10.1007/s00125-011-2345-8

Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients

K V Hendriksen, Tonny Joran Jensen, P Oturai, B Feldt-Rasmussen

Afdeling for Klinisk Fysiologi og Nuklearmedicin DIA

8 Citationer (Scopus)

Abstract

In type 2 diabetic patients, insulin detemir (B29Lys(ε-tetradecanoyl),desB30 human insulin) induces less weight gain than NPH insulin. Due to the proposed reduction of tubular action by insulin detemir, type 2 diabetic patients should have increased urinary sodium excretion, thereby reducing extracellular volume and body weight when changed from NPH insulin to insulin detemir.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	55
Udgave nummer	1
Sider (fra-til)	46-50
Antal sider	5
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-011-2345-8
Status	Udgivet - 2012

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abstract = "In type 2 diabetic patients, insulin detemir (B29Lys(ε-tetradecanoyl),desB30 human insulin) induces less weight gain than NPH insulin. Due to the proposed reduction of tubular action by insulin detemir, type 2 diabetic patients should have increased urinary sodium excretion, thereby reducing extracellular volume and body weight when changed from NPH insulin to insulin detemir.",

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author = "Hendriksen, \{K V\} and Jensen, \{Tonny Joran\} and P Oturai and B Feldt-Rasmussen",

year = "2012",

doi = "10.1007/s00125-011-2345-8",

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T1 - Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients

AU - Hendriksen, K V

AU - Jensen, Tonny Joran

AU - Oturai, P

AU - Feldt-Rasmussen, B

PY - 2012

Y1 - 2012

N2 - In type 2 diabetic patients, insulin detemir (B29Lys(ε-tetradecanoyl),desB30 human insulin) induces less weight gain than NPH insulin. Due to the proposed reduction of tubular action by insulin detemir, type 2 diabetic patients should have increased urinary sodium excretion, thereby reducing extracellular volume and body weight when changed from NPH insulin to insulin detemir.

AB - In type 2 diabetic patients, insulin detemir (B29Lys(ε-tetradecanoyl),desB30 human insulin) induces less weight gain than NPH insulin. Due to the proposed reduction of tubular action by insulin detemir, type 2 diabetic patients should have increased urinary sodium excretion, thereby reducing extracellular volume and body weight when changed from NPH insulin to insulin detemir.

KW - Aged

KW - Body Composition

KW - Cross-Over Studies

KW - Diabetes Mellitus, Type 2

KW - Extracellular Fluid

KW - Fluid Shifts

KW - Glomerular Filtration Rate

KW - Humans

KW - Hypoglycemic Agents

KW - Insulin, Isophane

KW - Insulin, Long-Acting

KW - Insulin, Regular, Human

KW - Middle Aged

KW - Outpatient Clinics, Hospital

KW - Patient Dropouts

KW - Sodium

KW - Time Factors

KW - Water-Electrolyte Balance

KW - Weight Loss

UR - https://www.scopus.com/pages/publications/84856702104

U2 - 10.1007/s00125-011-2345-8

DO - 10.1007/s00125-011-2345-8

M3 - Journal article

C2 - 22002075

SN - 0012-186X

VL - 55

SP - 46

EP - 50

JO - Diabetologia

JF - Diabetologia

IS - 1

ER -

Effects of insulin detemir and NPH insulin on renal handling of sodium, fluid retention and weight in type 2 diabetic patients

Abstract

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