Effects of glutamine on the immune system: Influence of muscular exercise and HIV infection

T. Rohde, H. Ullum, J. Palmo Rasmussen, J. H. Kristensen, E. Newsholme, B. K. Pedersen*

*Corresponding author af dette arbejde
61 Citationer (Scopus)


Glutamine increased the proliferative response and the lymphokine- activated killer cell activity of blood mononuclear cells isolated from normal healthy subjects (n = 6) in a dose-dependent manner, with optimum at 0.3-1.0 mM. The relative fraction of CD3+, CD4+, CD8+, CD14+, CD16+, and CD19+ cells was not changed by glutamine at a concentration of 0.6 mM, except in the phytohemagglutinin-stimulated proliferation experiment where the fraction of CD4+, and therefore CD3+ cells, increased. The natural killer cell activity was not influenced by glutamine. Human immunodeficiency virus (HIV)-seropositive subjects (n = 8) who performed concentric bicycle exercise for 1 h at 75% of maximal O2 consumption had an overall lower phytohemagglutinin-stimulated proliferative response, compared with the HIV- seronegative control group (n = 7). The proliferation during exercise was lower in both the HIV-seropositive and the HIV-seronegative group. Addition of glutamine in vitro did not normalize the lower proliferation in the HIV- seropositive group or the attenuated proliferation seen during exercise in both groups.

TidsskriftJournal of Applied Physiology
Udgave nummer1
Sider (fra-til)146-150
Antal sider5
StatusUdgivet - 1995
Udgivet eksterntJa


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