Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals

Siv H Jacobsen; Kirstine N Bojsen-Møller; Carsten Dirksen; Nils B Jørgensen; Trine R Clausen; Birgitte S Wulff; Viggo B Kristiansen; Dorte Worm; Dorte L Hansen; Jens Juul Holst; Gerrit van Hall; Sten Madsbad

doi:10.1007/s00125-013-3003-0

Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals

Siv H Jacobsen, Kirstine N Bojsen-Møller, Carsten Dirksen, Nils B Jørgensen, Trine R Clausen, Birgitte S Wulff, Viggo B Kristiansen, Dorte Worm, Dorte L Hansen, Jens Juul Holst, Gerrit van Hall, Sten Madsbad

106 Citationer (Scopus)

Abstract

Roux-en-Y gastric bypass surgery (RYGB) improves glucose tolerance in patients with type 2 diabetes, but also changes the glucose profile in response to a meal in glucose-tolerant individuals. We hypothesised that the driving force for the changed postprandial glucose profiles after RYGB is rapid entry of glucose into the systemic circulation due to modified gastrointestinal anatomy, causing hypersecretion of insulin and other hormones influencing glucose disappearance and endogenous glucose production.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	56
Udgave nummer	10
Sider (fra-til)	2250-4
Antal sider	5
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-013-3003-0
Status	Udgivet - okt. 2013

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10.1007/s00125-013-3003-0

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Jacobsen, S. H., Bojsen-Møller, K. N., Dirksen, C., Jørgensen, N. B., Clausen, T. R., Wulff, B. S., Kristiansen, V. B., Worm, D., Hansen, D. L., Holst, J. J., van Hall, G., & Madsbad, S. (2013). Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals. Diabetologia, 56(10), 2250-4. https://doi.org/10.1007/s00125-013-3003-0

Jacobsen, SH , Bojsen-Møller, KN , Dirksen, C, Jørgensen, NB, Clausen, TR, Wulff, BS, Kristiansen, VB , Worm, D , Hansen, DL, Holst, JJ, van Hall, G & Madsbad, S 2013, 'Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals', Diabetologia, bind 56, nr. 10, s. 2250-4. https://doi.org/10.1007/s00125-013-3003-0

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title = "Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals",

abstract = "Roux-en-Y gastric bypass surgery (RYGB) improves glucose tolerance in patients with type 2 diabetes, but also changes the glucose profile in response to a meal in glucose-tolerant individuals. We hypothesised that the driving force for the changed postprandial glucose profiles after RYGB is rapid entry of glucose into the systemic circulation due to modified gastrointestinal anatomy, causing hypersecretion of insulin and other hormones influencing glucose disappearance and endogenous glucose production.",

author = "Jacobsen, {Siv H} and Bojsen-M{\o}ller, {Kirstine N} and Carsten Dirksen and J{\o}rgensen, {Nils B} and Clausen, {Trine R} and Wulff, {Birgitte S} and Kristiansen, {Viggo B} and Dorte Worm and Hansen, {Dorte L} and Holst, {Jens Juul} and {van Hall}, Gerrit and Sten Madsbad",

year = "2013",

month = oct,

doi = "10.1007/s00125-013-3003-0",

language = "English",

volume = "56",

pages = "2250--4",

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TY - JOUR

T1 - Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals

AU - Jacobsen, Siv H

AU - Bojsen-Møller, Kirstine N

AU - Dirksen, Carsten

AU - Jørgensen, Nils B

AU - Clausen, Trine R

AU - Wulff, Birgitte S

AU - Kristiansen, Viggo B

AU - Worm, Dorte

AU - Hansen, Dorte L

AU - Holst, Jens Juul

AU - van Hall, Gerrit

AU - Madsbad, Sten

PY - 2013/10

Y1 - 2013/10

N2 - Roux-en-Y gastric bypass surgery (RYGB) improves glucose tolerance in patients with type 2 diabetes, but also changes the glucose profile in response to a meal in glucose-tolerant individuals. We hypothesised that the driving force for the changed postprandial glucose profiles after RYGB is rapid entry of glucose into the systemic circulation due to modified gastrointestinal anatomy, causing hypersecretion of insulin and other hormones influencing glucose disappearance and endogenous glucose production.

AB - Roux-en-Y gastric bypass surgery (RYGB) improves glucose tolerance in patients with type 2 diabetes, but also changes the glucose profile in response to a meal in glucose-tolerant individuals. We hypothesised that the driving force for the changed postprandial glucose profiles after RYGB is rapid entry of glucose into the systemic circulation due to modified gastrointestinal anatomy, causing hypersecretion of insulin and other hormones influencing glucose disappearance and endogenous glucose production.

U2 - 10.1007/s00125-013-3003-0

DO - 10.1007/s00125-013-3003-0

M3 - Journal article

C2 - 23893303

SN - 0012-186X

VL - 56

SP - 2250

EP - 2254

JO - Diabetologia

JF - Diabetologia

IS - 10

ER -

Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals

Abstract

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