Effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel of healthy subjects

V L Jørgensen; M Ibsen; L Andresen; J D Schulzke; A Perner

doi:10.1111/j.1399-6576.2007.01381.x

Effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel of healthy subjects

V L Jørgensen, M Ibsen, L Andresen, J D Schulzke, A Perner

11 Citationer (Scopus)

Abstract

Increased permeability and increased luminal concentrations of L-lactate have previously been shown in the large bowel in septic patients. To advance these observations, a human model of colorectal barrier failure in sepsis is desirable. Therefore, we assessed the effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel in healthy subjects.

Originalsprog	Engelsk
Tidsskrift	Acta Anaesthesiologica Scandinavica
Vol/bind	51
Udgave nummer	8
Sider (fra-til)	1085-92
Antal sider	8
ISSN	0001-5172
DOI	https://doi.org/10.1111/j.1399-6576.2007.01381.x
Status	Udgivet - sep. 2007

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10.1111/j.1399-6576.2007.01381.x

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abstract = "Increased permeability and increased luminal concentrations of L-lactate have previously been shown in the large bowel in septic patients. To advance these observations, a human model of colorectal barrier failure in sepsis is desirable. Therefore, we assessed the effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel in healthy subjects.",

keywords = "Adult, Apoptosis, Biological Markers, Cross-Over Studies, Endotoxemia, Endotoxins, Humans, Inflammation, Intestinal Absorption, Lactic Acid, Male, Nitric Oxide Synthase Type II, Protein C, Rectum, Tumor Necrosis Factors",

author = "J{\o}rgensen, {V L} and M Ibsen and L Andresen and Schulzke, {J D} and A Perner",

year = "2007",

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doi = "10.1111/j.1399-6576.2007.01381.x",

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T1 - Effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel of healthy subjects

AU - Jørgensen, V L

AU - Ibsen, M

AU - Andresen, L

AU - Schulzke, J D

AU - Perner, A

PY - 2007/9

Y1 - 2007/9

N2 - Increased permeability and increased luminal concentrations of L-lactate have previously been shown in the large bowel in septic patients. To advance these observations, a human model of colorectal barrier failure in sepsis is desirable. Therefore, we assessed the effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel in healthy subjects.

AB - Increased permeability and increased luminal concentrations of L-lactate have previously been shown in the large bowel in septic patients. To advance these observations, a human model of colorectal barrier failure in sepsis is desirable. Therefore, we assessed the effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel in healthy subjects.

KW - Adult

KW - Apoptosis

KW - Biological Markers

KW - Cross-Over Studies

KW - Endotoxemia

KW - Endotoxins

KW - Humans

KW - Inflammation

KW - Intestinal Absorption

KW - Lactic Acid

KW - Male

KW - Nitric Oxide Synthase Type II

KW - Protein C

KW - Rectum

KW - Tumor Necrosis Factors

U2 - 10.1111/j.1399-6576.2007.01381.x

DO - 10.1111/j.1399-6576.2007.01381.x

M3 - Journal article

C2 - 17697304

SN - 0001-5172

VL - 51

SP - 1085

EP - 1092

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 8

ER -

Effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel of healthy subjects

Abstract

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