Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Effects of early and late-onset treatment with carvedilol in an experimental model of aortic regurgitation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Associations between adherence, depressive symptoms and health-related quality of life in young adults with cystic fibrosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prognostic value of ratio of transmitral early filling velocity to early diastolic strain rate in patients with Type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Utility of left atrial strain for predicting atrial fibrillation following ischemic stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. An echocardiographic substrate for dyspnea identifies high risk patients with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The association between physical activity and cardiac performance is dependent on age: the Copenhagen City Heart Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Beta-blockade is contraindicated in severe aortic regurgitation (AR) due to the fear of prolonging diastole and thus aggravate regurgitation. However, this has never been scientifically proven and positive effects of targeting the sympathetic system in AR has been demonstrated in several studies.

METHOD: Thirty-nine Sprague-Dawley rats with AR were randomized to ten weeks of medical treatment with carvedilol or no treatment. Treatment was initiated either early or late after AR induction. The effect of carvedilol was assessed by serial echocardiography and invasive hemodynamic measurements.

RESULTS: AR resulted in eccentric hypertrophy and left ventricular (LV) dysfunction. LV remodeling and function as measured by echocardiography was unaffected by treatment. LV dimensions were similar between treated and untreated groups and measures of LV performance (including strain and strain rate) were also unaltered. This result was confirmed by invasive measurements showing maximal and minimal pressure-time development, LV volumes, and LV pressures, to be unaltered by treatment. On the contrary, despite relative bradycardia carvedilol did not reflect any negative impact on the heart.

CONCLUSION: Carvedilol did not improve left ventricular remodeling or function in rats with surgically induced AR. Despite relative bradycardia, we did not find carvedilol to negatively impact the heart, either when treatment was initiated early or late in the course of disease.

OriginalsprogEngelsk
TidsskriftSpringerPlus
Vol/bind4
Sider (fra-til)52
ISSN2193-1801
DOI
StatusUdgivet - 2015

ID: 45334532