Effects of an acute bolus growth hormone infusion on the human immune system

M. Kappel*, M. B. Hansen, M. Diamant, J. O.L. Jorgensen, A. Gyhrs, B. K. Pedersen

*Corresponding author af dette arbejde
63 Citationer (Scopus)

Abstract

This study was performed to examine the in vivo effects of a bolus of recombinant human growth hormone (r-hGH) on the human immune system. In a double blind placebo controlled cross over study, healthy volunteers were given 2 IU r-hGH as an intravenous infusion. r-hGH did not influence the subpopulations of blood mononuclear cells (BMNC), natural killer cell activity, in vitro proliferative responses or production of interleukin-1α (IL-1α),IL-1β, IL-2, IL-6, IL-8, tumor necrosis factor α (TNFα), TNFβ or interferon γ in supernatants from BMNC stimulated with either lipopolysaccharide or phytohemagglutinin. However, two h after infusion a significant neutrocytosis occurred. It is concluded that a bolus infusion of r-hGH to healthy volunteers exerts only minor effects on the human immune system.

OriginalsprogEngelsk
TidsskriftHormone and Metabolic Research
Vol/bind25
Udgave nummer11
Sider (fra-til)579-585
Antal sider7
ISSN0018-5043
DOI
StatusUdgivet - 1993
Udgivet eksterntJa

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