Abstract
This study was performed to examine the in vivo effects of a bolus of recombinant human growth hormone (r-hGH) on the human immune system. In a double blind placebo controlled cross over study, healthy volunteers were given 2 IU r-hGH as an intravenous infusion. r-hGH did not influence the subpopulations of blood mononuclear cells (BMNC), natural killer cell activity, in vitro proliferative responses or production of interleukin-1α (IL-1α),IL-1β, IL-2, IL-6, IL-8, tumor necrosis factor α (TNFα), TNFβ or interferon γ in supernatants from BMNC stimulated with either lipopolysaccharide or phytohemagglutinin. However, two h after infusion a significant neutrocytosis occurred. It is concluded that a bolus infusion of r-hGH to healthy volunteers exerts only minor effects on the human immune system.
Originalsprog | Engelsk |
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Tidsskrift | Hormone and Metabolic Research |
Vol/bind | 25 |
Udgave nummer | 11 |
Sider (fra-til) | 579-585 |
Antal sider | 7 |
ISSN | 0018-5043 |
DOI | |
Status | Udgivet - 1993 |
Udgivet eksternt | Ja |