TY - JOUR
T1 - Effect of non-pharmacological interventions on symptoms and quality of life in patients with hematological malignancies - a systematic review
AU - Pedersen, Maja
AU - Engedal, Mette Schaufuss
AU - Tolver, Anders
AU - Larsen, Maria Torp
AU - Kornblit, Brian Thomas
AU - Lomborg, Kirsten
AU - Jarden, Mary
N1 - Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2024/4
Y1 - 2024/4
N2 - BACKGROUND: Non-pharmacological interventions have the potential to enhance health-related quality of life (HRQoL) through symptom management. This systematic review aims to identify, collate, and assess randomized controlled trials investigating the effect of non-pharmacological interventions on symptoms and HRQoL within hematology.METHODS: MEDLINE/PUBMED, EMBASE, CINAHL, PSYCINFO and COCHRANE were searched up to April 2021. Outcomes were changes in symptoms and HRQoL.RESULTS: Sixty-five studies were categorized into five intervention types: Mind/body (n=9), Web-based (n=9), Music/art (n=6), Consultation-based (n=4), and Physical activity (n=37). We found significantly reduced fatigue (n=12 studies), anxiety (n=8) and depression (n=7), with 11 studies showing significant improvements in HRQoL.CONCLUSIONS: The evidence for non-pharmacological interventions shows substantial variation in efficacy and methodological quality. While specific symptoms and HRQoL outcomes significantly favored the intervention, no particular intervention can be emphasized as more favorable, given the inability to conduct a meta-analysis.
AB - BACKGROUND: Non-pharmacological interventions have the potential to enhance health-related quality of life (HRQoL) through symptom management. This systematic review aims to identify, collate, and assess randomized controlled trials investigating the effect of non-pharmacological interventions on symptoms and HRQoL within hematology.METHODS: MEDLINE/PUBMED, EMBASE, CINAHL, PSYCINFO and COCHRANE were searched up to April 2021. Outcomes were changes in symptoms and HRQoL.RESULTS: Sixty-five studies were categorized into five intervention types: Mind/body (n=9), Web-based (n=9), Music/art (n=6), Consultation-based (n=4), and Physical activity (n=37). We found significantly reduced fatigue (n=12 studies), anxiety (n=8) and depression (n=7), with 11 studies showing significant improvements in HRQoL.CONCLUSIONS: The evidence for non-pharmacological interventions shows substantial variation in efficacy and methodological quality. While specific symptoms and HRQoL outcomes significantly favored the intervention, no particular intervention can be emphasized as more favorable, given the inability to conduct a meta-analysis.
KW - Hematology
KW - Malignancy
KW - Non-pharmacological interventions
KW - Quality of life
KW - Symptom management
KW - Systematic review
KW - Humans
KW - Quality of Life
KW - Hematologic Neoplasms/therapy
KW - Randomized Controlled Trials as Topic
UR - https://www.scopus.com/pages/publications/85188822546
U2 - 10.1016/j.critrevonc.2024.104327
DO - 10.1016/j.critrevonc.2024.104327
M3 - Review
C2 - 38484899
SN - 1040-8428
VL - 196
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 104327
ER -