Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hypoxia-induced vagal withdrawal is independent of the hypoxic ventilatory response in men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Training state and skeletal muscle autophagy in response to 36 h of fasting

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Long-acting neurotensin synergizes with liraglutide to reverse obesity through a Melanocortin-dependent pathway

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Acute intramyocardial lipid accumulation in rats does not slow cardiac conduction per se

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

The axis of apolipoprotein M (apoM) and sphingosine-1-phosphate (S1P) is of importance to plasma lipid levels, endothelial function, and development of atherosclerosis. Menopause is accompanied by dyslipidemia and an increased risk of atherosclerosis, which can be lowered by exercise training. The aim of this study was to explore if effects of menopause and training are paralleled by changes in the apoM/S1P axis. Healthy, late premenopausal [ n = 38, age 49.2 (SD 2)] and recent postmenopausal [ n = 37, age 53.3 (SD 3)] women from the Copenhagen Women Study participated in a 3-mo, aerobic high-intensity exercise intervention. Before training, plasma apoM was higher in postmenopausal [1.08 µmol/l (SD 0.2)] compared with premenopausal [0.82 µmol/l (SD 0.2)] women ( P < 0.0001). Plasma S1P was similar in the two groups [0.44 µmol/l (SD 0.1) and 0.46 µmol/l (SD 0.1), respectively]. Thus, the pretraining S1P/apoM ratio was 26% lower in postmenopausal than premenopausal women ( P < 0.0001). After the training program, plasma apoM increased from 0.82 µmol/l (SD 0.2) to 0.90 µmol/l (SD 0.3) in premenopausal women and from 1.08 µmol/l (SD 0.2) to 1.16 µmol/l (SD 0.3) in postmenopausal women ( P < 0.05). Plasma S1P increased from 0.44 µmol/l (SD 0.1) to 0.47 µmol/l (SD 0.1) in premenopausal women and from 0.46 µmol/l (SD 0.1) to 0.48 µmol/l (SD 0.1) in postmenopausal women ( P < 0.05). The results suggest that menopause is accompanied by higher plasma apoM but not S1P concentrations and that exercise training increases plasma apoM and S1P in healthy middle-aged women irrespective of menopausal status. NEW & NOTEWORTHY The apolipoprotein M/sphingosine-1-phosphate (apoM/S1P) complex is involved in maintaining a healthy endothelial barrier function. Our study is the first, to our knowledge, to show how menopause affects the apoM/S1P axis. The results suggest that menopause is accompanied by higher plasma apoM but not S1P concentrations. Second, to our knowledge the study is also the first to show that exercise training increases both apoM/S1P in women irrespective of menopausal status.

OriginalsprogEngelsk
TidsskriftJournal of Applied Physiology
Vol/bind126
Udgave nummer1
Sider (fra-til)214-220
Antal sider7
ISSN0161-7567
DOI
StatusUdgivet - 1 jan. 2019

ID: 58286899