Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Effect of Melatonin on Sleep in the Perioperative Period after Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Normal Morning MCH Levels and No Association with REM or NREM Sleep Parameters in Narcolepsy Type 1 and Type 2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of biological therapy on the risk of sleep apnea in patients with psoriasis

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Psoriasis and Sleep Apnea: A Danish Nationwide Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Adverse reactions of dimethyl sulfoxide in humans: a systematic review [version 2; peer review: 2 approved with reservations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Exercise-Based Rehabilitation for Heart Failure: Cochrane Systematic Review, Meta-Analysis, and Trial Sequential Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A national center for persistent severe pain after groin hernia repair: Five-year prospective data

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Response to Comment on "Polypropylene Mesh and Fertility"

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Patient experience of spinal immobilisation after trauma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

STUDY OBJECTIVES: To investigate whether administration of an oral dose of 6 mg melatonin before bedtime perioperatively in breast cancer surgery could change sleep outcomes measured by actigraphy.

METHODS: This paper reports secondary outcomes from a double-blind, placebo-controlled, randomized clinical trial where patients received 6 mg melatonin (n = 27) or placebo (n = 21) approximately 60 minutes before bedtime 3 nights preoperatively until at least one week postoperatively. Participants were monitored in the entire period with actigraphy, and were instructed to complete visual analogue scale (VAS) for sleep, and the Karolinska Sleepiness Scale (KSS) each morning.

RESULTS: Administration of 6 mg oral melatonin approximately 1 hour before bedtime resulted in significantly increased sleep efficiency and reduced wake after sleep onset for the entire 2-week postoperative period. No other significant differences for actigraphy determined sleep outcomes or subjective outcome parameters in the perioperative period were found between the groups. Overall, the patients sleep outcomes were within normal ranges and no participants had pathological sleep disturbances.

CONCLUSIONS: Melatonin significantly changed sleep efficiency and wake after sleep onset after surgery, but had no effects on other objective sleep outcomes or on subjective sleep quality (VAS and KSS).

TRIAL REGISTRATION: The trial was registered on www.clinicaltrials.gov (NCT01355523) before inclusion of the first patient.

OriginalsprogEngelsk
TidsskriftJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Vol/bind12
Udgave nummer2
Sider (fra-til)225-233
ISSN1550-9389
StatusUdgivet - 2016

ID: 45661808